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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Blood glutathione and subclinical atherosclerosis in African men: The SABPA study
American Journal of Hypertension, Volume 22, No. 11, Year 2009
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Description
BackgroundSub-Saharan Africans face an increasing burden of hypertension and related cardiac and cerebrovascular morbidity and mortality, making the identification of factors leading to early vascular abnormalities imperative.MethodsWe investigated the possible influence of the antioxidant glutathione (GSH) on early subclinical atherosclerosis in 63 hypertensive (aged 45.2 years) and 34 normotensive (aged 38.9 years; P 0.001) nondiabetic African men. We measured ambulatory daytime systolic and diastolic blood pressure (SBP, DBP) as well as daytime mean arterial pressure (MAP), carotid intima-media thickness (CIMT), and calculated the cross-sectional wall area. We determined the reduced form of GSH in whole blood and blood glucose in serum.ResultsBlood glucose (110 vs. 92 mg/dl; P 0.001) and CIMT (0.75 vs. 0.61 mm; P 0.001) were higher in hypertensives compared to normotensives. No significant difference existed for GSH. Associations in normotensives suggested the hypotensive effect of GSH after single (SBP: r = 0.35, P 0.05; DBP: r = 0.37, P 0.05; MAP: r = 0.38, P 0.05) and multiple (SBP: B = 0.015, P 0.05; DBP: B = 0.011, P 0.05; MAP: B = 0.012, P 0.05) regression analyses. In hypertensives, CIMT (B = 0.00027, P 0.01) and cross-sectional wall area (CSWA) (B = 0.0066, P 0.05) correlated negatively with GSH. These findings were consistent after excluding 10 human immunodeficiency virus (HIV)-positive hypertensive subjects.ConclusionsIn hypertensive African men, CIMT is negatively associated with GSH, suggesting a possible contributory role of attenuated GSH levels in the development of subclinical atherosclerosis. © 2009 American Journal of Hypertension, Ltd.
Authors & Co-Authors
Schutte, Rudolph
South Africa, Potchefstroom
North-west University
Schutte, Aletta E.
South Africa, Potchefstroom
North-west University
Huisman, Hugo Willem
South Africa, Potchefstroom
North-west University
Van Rooyen, Johannes Marthinus
South Africa, Potchefstroom
North-west University
Malan, Nicolaas Theodor
South Africa, Potchefstroom
North-west University
Péter, Szabolcs
South Africa, Potchefstroom
North-west University
Fourie, Carla M. T. Maria Theresia
South Africa, Potchefstroom
North-west University
Van Der Westhuizen, F. H.
South Africa, Potchefstroom
North-west University
Louw, Roan
South Africa, Potchefstroom
North-west University
Botha, Cindy A.
South Africa, Potchefstroom
North-west University
Malan, Leoné
South Africa, Potchefstroom
North-west University
Statistics
Citations: 50
Authors: 11
Affiliations: 1
Identifiers
Doi:
10.1038/ajh.2009.158
ISSN:
08957061
Research Areas
Infectious Diseases
Noncommunicable Diseases
Study Design
Cross Sectional Study
Participants Gender
Male