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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
The trans-ancestral genomic architecture of glycemic traits
Nature Genetics, Volume 53, No. 6, Year 2021
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Description
Glycemic traits are used to diagnose and monitor type 2 diabetes and cardiometabolic health. To date, most genetic studies of glycemic traits have focused on individuals of European ancestry. Here we aggregated genome-wide association studies comprising up to 281,416 individuals without diabetes (30% non-European ancestry) for whom fasting glucose, 2-h glucose after an oral glucose challenge, glycated hemoglobin and fasting insulin data were available. Trans-ancestry and single-ancestry meta-analyses identified 242 loci (99 novel; P < 5 × 10−8), 80% of which had no significant evidence of between-ancestry heterogeneity. Analyses restricted to individuals of European ancestry with equivalent sample size would have led to 24 fewer new loci. Compared with single-ancestry analyses, equivalent-sized trans-ancestry fine-mapping reduced the number of estimated variants in 99% credible sets by a median of 37.5%. Genomic-feature, gene-expression and gene-set analyses revealed distinct biological signatures for each trait, highlighting different underlying biological pathways. Our results increase our understanding of diabetes pathophysiology by using trans-ancestry studies for improved power and resolution. © 2021, The Author(s), under exclusive licence to Springer Nature America, Inc.
Authors & Co-Authors
Chen, Ji
United Kingdom, Exeter
University of Exeter
United Kingdom, Hinxton
Wellcome Sanger Institute
Spracklen, Cassandra N.
United States, Chapel Hill
The University of North Carolina at Chapel Hill
United States, Amherst
University of Massachusetts Amherst
Marenne, Gaëlle
United Kingdom, Hinxton
Wellcome Sanger Institute
France, Paris
Inserm
Varshney, Arushi
United States, Ann Arbor
University of Michigan, Ann Arbor
Corbin, Laura J.
United Kingdom, Bristol
University of Bristol
Luan, Jian'fan N.An
United Kingdom, Cambridge
University of Cambridge
Willems, Sara M.
United Kingdom, Cambridge
University of Cambridge
Wu, Ying
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Zhang, Xiaoshuai
United Kingdom, Cambridge
University of Cambridge
China, Jinan
Shandong University
Horikoshi, Momoko
United Kingdom, Oxford
University of Oxford
Japan, Yokohama
Riken Center for Integrative Medical Sciences
Boutin, Thibaud S.
United Kingdom, Edinburgh
The University of Edinburgh
Mägi, Reedik
Estonia, Tartu
Tartu Ülikool
Waage, Johannes
Denmark, Copenhagen
Københavns Universitet
Li-Gao, Ruifang
Netherlands, Leiden
Leids Universitair Medisch Centrum
Chan, Kei Hang Katie
United States, Providence
Brown University
Hong Kong, Hong Kong
City University of Hong Kong
Yao, Jie
United States, Torrance
The Lundquist Institute
Anasanti, Mila Desi
United Kingdom, London
Imperial College London
Chu, Audrey Y.
United States, Boston
Brigham and Women's Hospital
Claringbould, Annique
Netherlands, Groningen
Rijksuniversiteit Groningen
Heikkinen, Jani
United Kingdom, London
Imperial College London
Hong, Jaeyoung
United States, Boston
School of Public Health
Hottenga, Jouke Jan
Netherlands, Amsterdam
Vrije Universiteit Amsterdam
Huo, Shaofeng
China, Beijing
Chinese Academy of Sciences
Kaakinen, Marika A.
United Kingdom, London
Imperial College London
United Kingdom, Guildford
University of Surrey
Louie, Tin L.
United States, Seattle
University of Washington
Mar̈z, Winfried
Germany, Munich
Synlab International Gmbh
Austria, Graz
Medizinische Universität Graz
Germany, Heidelberg
Universität Heidelberg
Moreno-Macías, Hortensia
Mexico, Mexico
Universidad Autónoma Metropolitana
Ndungu, Anne Wanjiru
United Kingdom, Oxford
University of Oxford
Nelson, Sarah C.
United States, Seattle
University of Washington
Nolte, Ilja Maria
Netherlands, Groningen
Rijksuniversiteit Groningen
North, Kari E.
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Raulerson, Chelsea K.
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Ray, Debashree
United States, Baltimore
Johns Hopkins Bloomberg School of Public Health
Rohde, Rebecca R.
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Rybin, Denis V.
United States, Boston
School of Public Health
Schurmann, Claudia
United States, New York
Icahn School of Medicine at Mount Sinai
Germany, Potsdam
Hasso-plattner-institut Für Softwaresystemtechnik Gmbh
Sim, Xueling
Singapore, Singapore City
National University Health System
United States, Ann Arbor
University of Michigan, Ann Arbor
Southam, Lorraine
United Kingdom, Hinxton
Wellcome Sanger Institute
Germany, Oberschleissheim
Helmholtz Center Munich German Research Center for Environmental Health
Stewart, Isobel D.
United Kingdom, Cambridge
University of Cambridge
Wang, Carol A.
Australia, Callaghan
University of Newcastle, College of Health, Medicine and Wellbeing
Wang, Yujie
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Wu, Peitao
United States, Boston
School of Public Health
Zhang, Weihua
United Kingdom, London
Imperial College London
United Kingdom, Harrow
London North West University Healthcare Nhs Trust
Ahluwalia, Tarunveer Singh
Denmark, Copenhagen
Københavns Universitet
Denmark, Herlev
Steno Diabetes Center Copenhagen
Appel, Emil Vincent Rosenbaum
Denmark, Copenhagen
Københavns Universitet
Bielak, Lawrence F.
United States, Ann Arbor
University of Michigan, Ann Arbor
Brody, Jennifer A.
United States, Seattle
University of Washington
Burtt, Nöel P.
United States, Cambridge
Broad Institute
Cabrera, Claudia P.
United Kingdom, London
Queen Mary University of London
Cade, Brian E.
United States, Boston
Brigham and Women's Hospital
United States, Boston
Harvard Medical School
Chai, Jinfang
Singapore, Singapore City
National University Health System
Chai, Xiaoran
Singapore, Singapore City
Singapore National Eye Centre
Singapore, Singapore City
National University Health System
Chang, Liching
Taiwan, Nankang
Academia Sinica Taiwan
Chen, Chien Hsiun
Taiwan, Nankang
Academia Sinica Taiwan
Chen, Brian H.
United States, San Diego
Human Longevity, Inc.
Chitrala, Kumaraswamy Naidu
United States, Bethesda
National Institutes of Health Nih
Chiu, Yen Feng
Taiwan, Zhunan
National Health Research Institutes Taiwan
de Haan, Hugoline G.
Netherlands, Leiden
Leids Universitair Medisch Centrum
Delgado, Graciela E.
Germany, Heidelberg
Universität Heidelberg
Demirkan, Ayşe
United Kingdom, Guildford
University of Surrey
Netherlands, Rotterdam
Erasmus Mc
Duan, Qing
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Engmann, Jorgen E.L.
United Kingdom, London
University College London
Fatumo, Segun A.
United Kingdom, London
London School of Hygiene & Tropical Medicine
Nigeria, Abuja
Centre for Genomics Research and Innovation
Gayán, Javier
Unknown Affiliation
Giulianini, Franco
United States, Boston
Brigham and Women's Hospital
Gong, Jung-ho
United States, Providence
Brown University
Gustafsson, Stefan
Sweden, Solna
Science for Life Laboratory
Hai, Yang
New Zealand, Auckland
The University of Auckland
Hartwig, Fernando Pires
United Kingdom, Bristol
University of Bristol
Brazil, Pelotas
Universidade Federal de Pelotas
He, Jing
United States, Nashville
Vanderbilt University Medical Center
Heianza, Yoriko
United States, New Orleans
Tulane University
Huang, Tao
China, Beijing
Peking University
Huerta-Chagoya, Alicia
Mexico, Mexico
Consejo Nacional de Humanidades, Ciencias y Tecnologías
Mexico, Tlalpan
Instituto Nacional de la Nutrición Salvador Zubiran
Hwang, Mi-yeong
South Korea, Cheongju
Korea National Institute of Health
Jensen, Richard A.
United States, Seattle
University of Washington
Kawaguchi, Takahisa
Japan, Kyoto
Graduate School of Medicine
Kentistou, Katherine A.
United Kingdom, Edinburgh
The University of Edinburgh
Kim, Young Jin
South Korea, Cheongju
Korea National Institute of Health
Kleber, Marcus Edi
Germany, Heidelberg
Universität Heidelberg
Kooner, Ishminder K.
United Kingdom, Harrow
London North West University Healthcare Nhs Trust
Lai, Shuiqing
United States, Providence
Brown University
Lange, Leslie A.
United States, Denver
University of Colorado Denver
Langefeld, Carl D.
United States, Winston Salem
Wake Forest University School of Medicine
Lauzon, Marie
United States, Torrance
The Lundquist Institute
Li, Man
United States, Salt Lake City
The University of Utah
Ligthart, Symen
Netherlands, Rotterdam
Erasmus Mc
Liu, Jun
Netherlands, Rotterdam
Erasmus Mc
United Kingdom, Oxford
University of Oxford
Loh, Marie Chiew Shia
United Kingdom, London
Imperial College London
Singapore, Singapore City
Nanyang Technological University
Long, Jirong
United States, Nashville
Vanderbilt University Medical Center
Lyssenko, Valeriya
Norway, Bergen
Universitetet I Bergen
Sweden, Malmo
Lund University Diabetes Centre
Mangino, Massimo
United Kingdom, London
King's College London
United Kingdom, London
Guy's and st Thomas' Nhs Foundation Trust
Marzi, Carola S.
Germany, Oberschleissheim
Helmholtz Center Munich German Research Center for Environmental Health
Germany, Oberschleissheim
Deutsches Zentrum Für Diabetesforschung
Montasser, May E.
United States, Baltimore
University of Maryland School of Medicine
Nag, Abhishek
United Kingdom, Oxford
University of Oxford
Nakatochi, Masahiro
Japan, Nagoya
Nagoya University Graduate School of Medicine
Noce, Damia
Italy, Bolzano
Eurac Research
Noordam, Raymond
Netherlands, Leiden
Leids Universitair Medisch Centrum
Pistis, Giorgio
Italy, Rome
Consiglio Nazionale Delle Ricerche
Preuss, Michael H.
United States, New York
Icahn School of Medicine at Mount Sinai
Raffield, Laura Marie
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Rasmussen-Torvik, Laura J.
United States, Chicago
Northwestern University Feinberg School of Medicine
Rich, Stephen S.
United States, Charlottesville
University of Virginia
Robertson, Neil R.
United Kingdom, Oxford
University of Oxford
Rueedi, Rico
Switzerland, Lausanne
Université de Lausanne Unil
Switzerland, Lausanne
Sib Swiss Institute of Bioinformatics
Sanna, Serena
Netherlands, Groningen
Rijksuniversiteit Groningen
Italy, Rome
Consiglio Nazionale Delle Ricerche
Saxena, Richa
United States, Boston
Massachusetts General Hospital
United States, Cambridge
Broad Institute
Schraut, Katharina E.
United Kingdom, Edinburgh
The University of Edinburgh
Sennblad, Bengt
Sweden, Solna
Science for Life Laboratory
Smith, Albert Vernon
United States, Ann Arbor
University of Michigan, Ann Arbor
Iceland, Kopavogur
Icelandic Heart Association
Sparsø, Thomas
Denmark, Copenhagen
Københavns Universitet
Strawbridge, Rona J.
United Kingdom, Glasgow
University of Glasgow
Sweden, Stockholm
Karolinska Institutet
Takeuchi, Fumihiko
Japan, Tokyo
National Center for Global Health and Medicine
Trompet, Stella
Netherlands, Leiden
Leids Universitair Medisch Centrum
van den Akker, Erik Ben
Netherlands, Leiden
Leids Universitair Medisch Centrum
Netherlands, Delft
Delft University of Technology
van der Most, Peter J.
Netherlands, Groningen
Rijksuniversiteit Groningen
Verweij, Niek
Netherlands, Groningen
Rijksuniversiteit Groningen
United Kingdom, Oxford
Genomics Plc
Wang, Heming
United States, Boston
Brigham and Women's Hospital
United States, Boston
Harvard Medical School
Wang, Nan
United States, Los Angeles
Keck School of Medicine of Usc
United States, Los Angeles
University of Southern California
Warren, Helen R.
United Kingdom, London
Queen Mary University of London
Wilsgaard, Tom
Norway, Tromso
Uit Norges Arktiske Universitet
Wong, A. Kin On
United Kingdom, London
Medical Research Council
Wood, Andrew R.
United Kingdom, Exeter
University of Exeter
Zafarmand, Mohammad Hadi
Netherlands, Amsterdam
Vrije Universiteit Amsterdam
Zhao, Jinghua
United Kingdom, Cambridge
University of Cambridge
Zhao, Wei
United States, Ann Arbor
University of Michigan, Ann Arbor
Amin, Najaf A.
Netherlands, Rotterdam
Erasmus Mc
United Kingdom, Oxford
University of Oxford
Astrup, Arne Vernon
Denmark, Copenhagen
Københavns Universitet
Bakker, Stephan J.L.
Netherlands, Groningen
Rijksuniversiteit Groningen
Baldassarre, D.
Italy, Milan
Università Degli Studi Di Milano
Italy, Milan
Irccs Centro Cardiologico Monzino
Beekman, Marian
Netherlands, Leiden
Leids Universitair Medisch Centrum
Bergman, Richard N.
United States, Los Angeles
Cedars-sinai Medical Center
Bertoni, Alain G.
United States, Winston Salem
Wake Forest University School of Medicine
Blüher, Matthias
Germany, Leipzig
Universität Leipzig
Bonnycastle, Lori L.C.
United States, Bethesda
National Institutes of Health Nih
Bornstein, Stefan R.
Germany, Dresden
Technische Universität Dresden
Bowden, Donald W.
United States, Winston Salem
Wake Forest University School of Medicine
Campbell, Archie I.
United Kingdom, Edinburgh
Western General Hospital
United Kingdom, Edinburgh
The University of Edinburgh
Campbell, Harry
United Kingdom, Edinburgh
The University of Edinburgh
de Geus, Eco J.C.N.
Netherlands, Amsterdam
Vrije Universiteit Amsterdam
Dehghan, Abbas
Netherlands, Rotterdam
Erasmus Mc
Eiríksdóttir, Gudný H.
Iceland, Kopavogur
Icelandic Heart Association
Fuchsberger, Christian
Italy, Bolzano
Eurac Research
Gao, Yutang
China, Shanghai
Shanghai Cancer Institute
Gjesing, Anette Prior
Denmark, Copenhagen
Københavns Universitet
Goel, Anuj
United Kingdom, Oxford
University of Oxford
Han, Sohee
South Korea, Cheongju
Korea National Institute of Health
Hartman, Catharina Annette
Netherlands, Groningen
Rijksuniversiteit Groningen
Herder, Christian
Germany, Dusseldorf
Heinrich-heine-universität Düsseldorf
Germany, Dusseldorf
Deutsches Diabetes-zentrum
Hicks, Andrew Anthony
Italy, Bolzano
Eurac Research
Ichihara, Sahoko
Japan, Kawachi District
Jichi Medical University
Ikram, Mohammad Arfan
Netherlands, Rotterdam
Erasmus Mc
Johnson, William Craig
United States, Seattle
University of Washington
Jørgensen, Marit E. Eika
Denmark, Herlev
Steno Diabetes Center Copenhagen
Denmark, Odense
Syddansk Universitet
Joshi, Peter K.
United Kingdom, Edinburgh
The University of Edinburgh
Kalyani, Rita Rastogi
United States, Baltimore
Johns Hopkins School of Medicine
Kandeel, Fouad R.
United States, Duarte
City of Hope National Med Center
Khor, Chiea Chuen
Singapore, Singapore City
Agency for Science, Technology and Research, Singapore
Kiess, Wieland
Germany, Leipzig
Universität Leipzig
Kolcic, Ivana
Croatia, Split
School of Medicine, University of Split
Kuusisto, Johanna K.
Finland, Kuopio
Kuopio University Hospital
Läll, Kristi
Estonia, Tartu
Tartu Ülikool
Lawlor, Debbie A.
United Kingdom, Bristol
University of Bristol
Mayol, Nanette L.
Philippines, Cebu
University of San Carlos
Lemaitre, Rozenn N.
United States, Seattle
University of Washington
Lindstr̈om, Jaana
Finland, Helsinki
Terveyden ja Hyvinvoinnin Laitos
Linneberg, Allan R.
Denmark, Copenhagen
Frederiksberg Hospital
Denmark, Copenhagen
Københavns Universitet
Liu, Jianjun
Singapore, Singapore City
Agency for Science, Technology and Research, Singapore
Singapore, Singapore City
National University Health System
Lorenzo, Carlos
United States, San Antonio
University of Texas Health Science Center at San Antonio
Matsuda, Fumihiko
Japan, Kyoto
Graduate School of Medicine
Mooijaart, Simon P.
Netherlands, Leiden
Leids Universitair Medisch Centrum
Nabika, Tohru
Japan, Izumo
Shimane University Faculty of Medicine
Nadkarni, Girish N.
United States, New York
Icahn School of Medicine at Mount Sinai
Nelis, Mari
Estonia, Tartu
Tartu Ülikool
Neville, Matt J.
United Kingdom, Oxford
University of Oxford
United Kingdom, Oxford
Oxford University Hospitals Nhs Foundation Trust
Norris, Jill M.
United States, Aurora
Colorado School of Public Health
Peters, Annette Michael
Germany, Oberschleissheim
Deutsches Zentrum Für Diabetesforschung
Germany, Oberschleissheim
Helmholtz Center Munich German Research Center for Environmental Health
Germany, Munich
Ludwig-maximilians-universität München
Peyser, Patricia A.
United States, Ann Arbor
University of Michigan, Ann Arbor
Polašek, Ozren
Croatia, Split
School of Medicine, University of Split
Qi, Qibin
United States, New York
Albert Einstein College of Medicine of Yeshiva University
Reilly, Dermot F.
United States, Rahway
Merck & Co., Inc.
Reiner, Alexander Paul
United States, Seattle
Fred Hutchinson Cancer Center
Rudan, Igor
United Kingdom, Edinburgh
The University of Edinburgh
Sattar, Naveed A.
United Kingdom, Glasgow
College of Medical, Veterinary & Life Sciences
Stringham, Heather M.
United States, Ann Arbor
University of Michigan, Ann Arbor
Taylor, Kent D.
United States, Torrance
The Lundquist Institute
Teslovich, Tanya M.
Unknown Affiliation
Thuesen, Betina Heinsbæk
Denmark, Copenhagen
Frederiksberg Hospital
Timmers, Paul R.H.J.
United Kingdom, Edinburgh
The University of Edinburgh
Tremoli, Elena
Italy, Milan
Irccs Centro Cardiologico Monzino
Tsai, Michael Y.
United States, Minneapolis
University of Minnesota Twin Cities
Uitterlinden, André G.
Netherlands, Rotterdam
Erasmus Mc
van Dam, Robertus Martinus
Singapore, Singapore City
National University Health System
United States, Boston
Harvard T.h. Chan School of Public Health
van Heemst, Diana
Netherlands, Leiden
Leids Universitair Medisch Centrum
van Hylckama-Vlieg, Astrid
Netherlands, Leiden
Leids Universitair Medisch Centrum
Wang, Tao
United States, New York
Albert Einstein College of Medicine of Yeshiva University
van Dijk, Ko Willems
Netherlands, Leiden
Leids Universitair Medisch Centrum
Zemunik, T.
Croatia, Split
School of Medicine, University of Split
Abecasis, Gonçalo R.
United States, Ann Arbor
University of Michigan, Ann Arbor
Adair, Linda S.
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Aguilar Salinas, Carlos A.
Mexico, Tlalpan
Instituto Nacional de la Nutrición Salvador Zubiran
Mexico, Monterrey
Tecnológico de Monterrey
Alarcón-Riquelme, Marta Eugenia
Spain, Granada
Universidad de Granada
Sweden, Stockholm
Karolinska Institutet
An, Ping
United States, St. Louis
Washington University School of Medicine in St. Louis
Becker, Diane M.
United States, Baltimore
Johns Hopkins School of Medicine
Beilin, Lawerence Joseph
Australia, Perth
The University of Western Australia
Bisgaard, Hans
Denmark, Copenhagen
Københavns Universitet
Boehnke, Michael L.
United States, Ann Arbor
University of Michigan, Ann Arbor
Boerwinkle, Eric A.
United States, Houston
University of Texas Health Science Center at Houston
United States, Houston
Baylor College of Medicine
Böhm, Bernhard O.
Germany, Ulm
Universität Ulm
United Kingdom, London
Imperial College London
Bønnelykke, Klaus
Denmark, Copenhagen
Københavns Universitet
Boomsma, Dorret I.
Netherlands, Amsterdam
Vrije Universiteit Amsterdam
Böttinger, Erwin P.
United States, New York
Icahn School of Medicine at Mount Sinai
Germany, Potsdam
Universität Potsdam
Buchanan, Thomas A.
United States, Los Angeles
University of Southern California
United States, Los Angeles
Keck School of Medicine of Usc
Canouil, Mickaël
France, Lille
Université de Lille
France, Lille
Epigénomique Fonctionnelle et Physiologie Moléculaire du Diabète et Maladies Associées
Caulfield, Mark J.
United Kingdom, London
Queen Mary University of London
Chambers, John Campbell
United Kingdom, London
Imperial College London
United Kingdom, Harrow
London North West University Healthcare Nhs Trust
Singapore, Singapore City
Nanyang Technological University
Chasman, Daniel I.
United States, Boston
Brigham and Women's Hospital
United States, Boston
Harvard Medical School
Chen, Yii Der Ida
United States, Torrance
The Lundquist Institute
Collins, Francis S.
United States, Bethesda
National Institutes of Health Nih
Correa, Adolfo
Unknown Affiliation
Cucca, Francesco
Italy, Rome
Consiglio Nazionale Delle Ricerche
de Silva, Hithanadura Janaka
Sri Lanka, Kelaniya
University of Kelaniya
Dedoussis, George V.Z.
Greece, Athens
Harokopio University of Athens
Elmstähl, Sölve I.
Sweden, Lund
Lunds Universitet
Evans, Michele Kim
United States, Bethesda
National Institutes of Health Nih
Ferrannini, Ele
Italy, Pisa
Istituto Di Fisiologia Clinica Del Cnr
Ferrucci, Luigi G.
United States, Bethesda
National Institute on Aging Nia
Florez, Jose C.
United States, Cambridge
Broad Institute
United States, Boston
Massachusetts General Hospital
United States, Boston
Harvard Medical School
Franks, Paul W.
Sweden, Malmo
Lund University Diabetes Centre
Sweden, Umea
Umeå Universitet
Frayling, Tim M.
United Kingdom, Exeter
University of Exeter
Froguel, Philippe
France, Lille
Université de Lille
France, Lille
Epigénomique Fonctionnelle et Physiologie Moléculaire du Diabète et Maladies Associées
United Kingdom, London
Imperial College London
Gigante, Bruna
Sweden, Stockholm
Karolinska Institutet
Goodarzi, Mark O.
United States, Los Angeles
Cedars-sinai Medical Center
Grallert, Harald
Germany, Oberschleissheim
Helmholtz Center Munich German Research Center for Environmental Health
Germany, Oberschleissheim
Deutsches Zentrum Für Diabetesforschung
Grarup, Niels
Denmark, Copenhagen
Københavns Universitet
Groop, Leif C.
Sweden, Lund
Lunds Universitet
Finland, Helsinki
Helsingin Yliopisto
Gudnason, V. G.
Iceland, Kopavogur
Icelandic Heart Association
Iceland, Reykjavik
Haskoli Islands
Guo, Xiuqing
United States, Torrance
The Lundquist Institute
Hamsten, Anders
Sweden, Stockholm
Karolinska Institutet
Hansen, Torben
Denmark, Copenhagen
Københavns Universitet
Hayward, Caroline
United Kingdom, Edinburgh
The University of Edinburgh
Heckbert, Susan R.
United States, Seattle
University of Washington
Horta, Bernardo Lessa
Brazil, Pelotas
Universidade Federal de Pelotas
Ingelsson, Erik
United States, Palo Alto
Stanford University
Pankow, Jim S.
United States, Minneapolis
University of Minnesota Twin Cities
J̈arvelin, Märjo Riitta R.
United Kingdom, London
Imperial College London
Finland, Oulu
Oulun Yliopisto
Finland, Oulu
Oulu University Hospital
United Kingdom, Uxbridge
Brunel University London
Jonas, Jost Bruno
Germany, Heidelberg
Universität Heidelberg
China, Beijing
Capital Medical University
Switzerland, Basel
Institute of Molecular and Clinical Ophthalmology Basel
Jukema, Johan Wouter
Netherlands, Leiden
Leids Universitair Medisch Centrum
Netherlands, Utrecht
Netherlands Heart Institute
Kaleebu, Pontiano P.
United Kingdom, London
London School of Hygiene & Tropical Medicine
Deloukas, Panos C.
United States, New York
Albert Einstein College of Medicine of Yeshiva University
United States, Seattle
Fred Hutchinson Cancer Center
Kardia, Sharon L.R.
United States, Ann Arbor
University of Michigan, Ann Arbor
Kato, Norihiro
Japan, Tokyo
National Center for Global Health and Medicine
Keinänen-Kiukaanniemi, Sirkka M.
Finland, Oulu
Oulun Yliopisto
Finland, Oulu
Oulu University Hospital
Kim, Bongjo
South Korea, Cheongju
Korea National Institute of Health
Kivimaki, Mika Shipley
United Kingdom, London
University College London
Koistinen, Heikki A.
Finland, Helsinki
Terveyden ja Hyvinvoinnin Laitos
Finland, Helsinki
Helsingin Yliopisto
Finland, Helsinki
Minerva Foundation Institute for Medical Research Helsinki
Kooner, Jaspal Singh
United Kingdom, Harrow
London North West University Healthcare Nhs Trust
United Kingdom, London
Imperial College London
Kor̈ner, Antje
Germany, Leipzig
Universität Leipzig
Kovács, Péter F.
Germany, Leipzig
Universität Leipzig
Kumari, Meena
United Kingdom, Colchester
University of Essex
Kutalik, Zoltán
Switzerland, Lausanne
Sib Swiss Institute of Bioinformatics
Switzerland, Lausanne
Université de Lausanne Unil
Laakso, M. M.
Finland, Kuopio
Kuopio University Hospital
Lakka, Timo Antero
Finland, Kuopio
Itä-suomen Yliopisto
Finland, Kuopio
Kuopio University Hospital
Launer, Lenore J.
United States, Bethesda
National Institutes of Health Nih
Leander, Karin
Sweden, Stockholm
Karolinska Institutet
Lind, Lars L.
Sweden, Uppsala
Uppsala Universitet
Lindgren, Cecilia M.
United Kingdom, Oxford
University of Oxford
Liu, Simin
United States, Providence
Brown University
Loos, Ruth J.F.
United States, New York
Icahn School of Medicine at Mount Sinai
Magnusson, Patrik K.E.
Sweden, Stockholm
Karolinska Institutet
Mahajan, Anubha
United Kingdom, Oxford
University of Oxford
United States, San Francisco
Genentech, Inc
Metspalu, Andres H.
Estonia, Tartu
Tartu Ülikool
Mook-Kanamori, Dennis Owen
Netherlands, Leiden
Leids Universitair Medisch Centrum
Mori, Trevor A.
Australia, Perth
The University of Western Australia
Munroe, Patricia B.
United Kingdom, London
Queen Mary University of London
NjØlstad, Inger
Norway, Tromso
Uit Norges Arktiske Universitet
Oldehinkel, Albertine J.(Tineke)
Netherlands, Groningen
Rijksuniversiteit Groningen
Ong, Ken K.L.
United Kingdom, Cambridge
University of Cambridge
Padmanabhan, Sandosh
United Kingdom, Glasgow
University of Glasgow
Palmer, Colin Neil Alexander
United Kingdom, Dundee
University of Dundee
Palmer, Nicholette (Nichole)
United States, Winston Salem
Wake Forest University School of Medicine
Pedersen, Oluf Borbye
Denmark, Copenhagen
Københavns Universitet
Pennell, Craig Edward
Australia, Callaghan
University of Newcastle, College of Health, Medicine and Wellbeing
Porteous, David John
United Kingdom, Edinburgh
Western General Hospital
United Kingdom, Edinburgh
The University of Edinburgh
Pramstaller, Peter P.
Italy, Bolzano
Eurac Research
Province, Michael A.
United States, St. Louis
Washington University School of Medicine in St. Louis
Psaty, Bruce M.
United States, Seattle
University of Washington
Qi, Lu
United States, New Orleans
Tulane University School of Public Health and Tropical Medicine
Rauramaa, Rainer
Finland, Kuopio
Itä-suomen Yliopisto
Redline, Susan S.
United States, Boston
Brigham and Women's Hospital
United States, Boston
Harvard Medical School
Ridker, Paul M.
United States, Boston
Brigham and Women's Hospital
United States, Boston
Harvard Medical School
Rosendaal, Frits Richard
Netherlands, Leiden
Leids Universitair Medisch Centrum
Saaristo, Timo E.
Finland, Tampere
Finnish Diabetes Association
Finland, Tampere
Pirkanmaan Sairaanhoitopiiri
Sandhu, Manjinder Singh
United Kingdom, Cambridge
University of Cambridge
Saramies, Jouko L.
Finland, Lappeenranta
South Karelia Central Hospital
Schwarz, Peter Ee H.
Germany, Oberschleissheim
Deutsches Zentrum Für Diabetesforschung
Germany, Dresden
Technische Universität Dresden
Germany, Dresden
Universitätsklinikum Carl Gustav Carus Dresden
Scott, Laura J.
United States, Ann Arbor
University of Michigan, Ann Arbor
Selvin, Elizabeth
United States, Baltimore
Johns Hopkins Bloomberg School of Public Health
Sever, Peter S.
United Kingdom, London
Imperial College London
Shu, Xiaoou
United States, Nashville
Vanderbilt University Medical Center
Slagboom, Pieternella Eline
Netherlands, Leiden
Leids Universitair Medisch Centrum
Small, Kerrin S.
United Kingdom, London
King's College London
Smith, Blair H.
United Kingdom, Dundee
University of Dundee
Snieder, Harold
Netherlands, Groningen
Rijksuniversiteit Groningen
Sofer, Tamar
United States, Boston
Harvard Medical School
United States, Boston
Brigham and Women's Hospital
Sorensen, Thorkild I.A.
United Kingdom, Bristol
University of Bristol
Denmark, Copenhagen
Københavns Universitet
Spector, Tim David
United Kingdom, London
King's College London
Stanton, Alice V.
Ireland, Dublin
Royal College of Surgeons in Ireland
Steves, Claire J.
United Kingdom, London
King's College London
United Kingdom, London
Guy's and st Thomas' Nhs Foundation Trust
Stumvoll, Michael W.
Germany, Leipzig
Universität Leipzig
Tai, E. Shyong
Singapore, Singapore City
National University Health System
Singapore, Singapore City
Duke-nus Medical School
Timpson, Nicholas J.
United Kingdom, Bristol
University of Bristol
Tönjes, Anke
Germany, Leipzig
Universität Leipzig
Tuomilehto, Jaakko O.I.
Finland, Helsinki
Terveyden ja Hyvinvoinnin Laitos
Finland, Helsinki
Helsingin Yliopisto
Saudi Arabia, Jeddah
King Abdulaziz University
Uusitupa, Matti
Finland, Kuopio
Itä-suomen Yliopisto
van der Harst, Pim
Netherlands, Groningen
Rijksuniversiteit Groningen
van Duijn, Cornelia M.
Netherlands, Rotterdam
Erasmus Mc
United Kingdom, Oxford
University of Oxford
Vitart, Véronique
United Kingdom, Edinburgh
The University of Edinburgh
Vollenweider, Peter K.
Switzerland, Lausanne
Centre Hospitalier Universitaire Vaudois
Wagenknecht, Lynne E.
United States, Winston Salem
Wake Forest University School of Medicine
Walker, Mark A.
United Kingdom, Newcastle
Newcastle University
Wang, Yaxing
China, Beijing
Capital Medical University
Wareham, Nicholas J.
United Kingdom, Cambridge
University of Cambridge
Watanabe, Richard M.
United States, Los Angeles
Keck School of Medicine of Usc
United States, Los Angeles
University of Southern California
Watkins, Hugh C.
United Kingdom, Oxford
University of Oxford
Wickramasinghe, Ananda Rajitha
Sri Lanka, Kelaniya
University of Kelaniya
Willemsen, Gonneke A.H.M.
Netherlands, Amsterdam
Vrije Universiteit Amsterdam
Wilson, James F.
United Kingdom, Edinburgh
The University of Edinburgh
Wong, Tienyin
Singapore, Singapore City
Singapore National Eye Centre
Singapore, Singapore City
Duke-nus Medical School
Wu, Jeryuarn
Taiwan, Nankang
Academia Sinica Taiwan
Xiang, Anny Hui
United States, Oakland
Kaiser Permanente
Yanek, Lisa R.
United States, Baltimore
Johns Hopkins School of Medicine
Yengo, Loic
Australia, Brisbane
The University of Queensland
Zeggini, Eleftheria
United Kingdom, Hinxton
Wellcome Sanger Institute
Germany, Oberschleissheim
Helmholtz Center Munich German Research Center for Environmental Health
Germany, Munich
Technische Universität München
Zheng, Wei
United States, Nashville
Vanderbilt University Medical Center
Zonderman, Alan B.
United States, Bethesda
National Institutes of Health Nih
Rotter, Jerome I.
United States, Torrance
The Lundquist Institute
Gloyn, Anna L.
United Kingdom, Oxford
University of Oxford
United Kingdom, Oxford
Oxford University Hospitals Nhs Foundation Trust
United States, Stanford
Stanford University School of Medicine
McCarthy, Mark I.
United Kingdom, Oxford
University of Oxford
United Kingdom, Oxford
Oxford University Hospitals Nhs Foundation Trust
United Kingdom, Oxford
The Wellcome Centre for Human Genetics
United States, San Francisco
Genentech, Inc
Dupuis, Josèe
United States, Boston
School of Public Health
Meigs, James B.
United States, Cambridge
Broad Institute
United States, Boston
Harvard Medical School
United States, Boston
Massachusetts General Hospital
Scott, Robert A.
United Kingdom, Cambridge
University of Cambridge
Prokopenko, Inga I.
United Kingdom, London
Imperial College London
United Kingdom, Guildford
University of Surrey
Leong, Aaron
United States, Boston
Harvard Medical School
United States, Boston
Massachusetts General Hospital
Liu, Chingti
United States, Boston
School of Public Health
Parker, Stephen C.J.
United States, Ann Arbor
University of Michigan, Ann Arbor
Mohlke, Karen
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Langenberg, Claudia C.
United Kingdom, Cambridge
University of Cambridge
Wheeler, Eleanor
United Kingdom, Hinxton
Wellcome Sanger Institute
United Kingdom, Cambridge
University of Cambridge
Morris, Andrew Paul
United Kingdom, Oxford
University of Oxford
United Kingdom, Manchester
The University of Manchester
United Kingdom, Liverpool
University of Liverpool
Barroso, Inês E.
United Kingdom, Exeter
University of Exeter
United Kingdom, Hinxton
Wellcome Sanger Institute
United Kingdom, Cambridge
University of Cambridge
van der Most, Peter J.
Netherlands, Groningen
Rijksuniversiteit Groningen
Statistics
Citations: 202
Authors: 351
Affiliations: 186
Identifiers
Doi:
10.1038/s41588-021-00852-9
ISSN:
10614036
Research Areas
Genetics And Genomics
Health System And Policy
Noncommunicable Diseases