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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Potentiometric determination of diazepam, bromazepam and clonazepam using solid contact ion-selective electrodes
Analytica Chimica Acta, Volume 498, No. 1-2, Year 2003
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Description
Newly developed solid contact ion-selective electrodes (SC-ISE) have been proposed for determining diazepam, bromazepam and clonazepam 1, 4-benzodiazepines in pure forms and in pharmaceutical preparations. The electrodes are based on polyvinylchloride (PVC) membranes doped with drug-tetraphenyl borate (TPB) or drug-phosphotungestic acid (PTA) ion pair complexes as electroactive materials. The new electrodes proved highly selective with selectivity coefficients ranging from 10-4 to 10 -6 and detection limits ranging from 0.1 to 0.63μg/ml. Successful application of developed electrodes for drugs determinations in pharmaceutical preparations was obtained. Calibration graphs were linear over the ranges of 0.29-71.20, 0.79-31.62 and 0.32-31.57μg/ml for diazepam, bromazepam and clonazepam, respectively with slopes of 50-65mV per decade in the optimum pH range of 4-7. Relative average errors ≤1.72% and relative standard deviations ≤1.13% were obtained. Statistical student's t-test and F-test showed insignificant systematic error between measured and real values and also between developed ion-selective electrodes methods and a standard HPLC method. © 2003 Elsevier B.V. All rights reserved.
Authors & Co-Authors
Salem, Alaa A.
United Arab Emirates, Al Ain
United Arab Emirates University
Egypt, Giza
Cairo University
Barsoum, Barsoum N.
Egypt, Giza
Faculty of Science
Izake, Emad L.
Egypt, Cairo
Ministry of Justice
Statistics
Citations: 74
Authors: 3
Affiliations: 4
Identifiers
Doi:
10.1016/j.aca.2003.08.070