BACKGROUND: Leptin is a novel adipocytokine that expresses the brain's energy reservoir status. It is considered to be an important food consumption and energy storage regulator. Thyroid function disturbance is associated with marked improvements in both body weight and energy consumption, and the respective functions of leptin and thyroid hormones in this regard have also been the focus of much research. In order to explore the potential interaction of serum leptin and thyroid hormones in Jordan, relatively little research has been conducted. The aim of this research was to find any potential connection in Jordanian hypothyroidism patients between serum leptin levels and thyroid hormones. METHODS: Seventy-one adult patients (15 males, 56 females) aged 1-74 were recruited from Al-Zarqa Governmental Hospital (Zarqa, Jordan) and Al-Bashir Hospital (Amman, Jordan) for thyroid disorders. Ninety-three healthy volunteers from the Jordanian population acted as monitors with no thyroid problems and no thyroid condition family history (19 males and 20 females). For each patient, body weight, height, and Body Mass Index (BMI, kg/m2) were calculated. By calculating overall fasting serum and free triiodothyronine (TT3, FT3), total and free thyroxine (TT4, FT4), and thyroid stimulating hormone, thyroid function was evaluated (TSH). RESULTS: The result revealed no clear association between serum leptin and T3, T4, FT3, FT4, TSHin the patient control group, either hypothyroid or euthyroid. Male serum leptin levels were smaller than those recorded in females (patients with hypothyroid; 10.2±3.43 and 11.6 ±4.03 ng/mL; P>0.05: Euthyroid; 4.44±1.48 and 7.41±2.0 ng/mL; P>0.05). CONCLUSIONS: Our outcome revealed no substantial association in both patient groups between leptin and thyroid hormone activity. Leptin levels, on the other hand, are strongly associated with BMI, and this may confirm that the primary determinant of leptin levels is BMIand gender.
