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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
general
Metabolite changes in blood predict the onset of tuberculosis
Nature Communications, Volume 9, No. 1, Article 5208, Year 2018
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Description
New biomarkers of tuberculosis (TB) risk and disease are critical for the urgently needed control of the ongoing TB pandemic. In a prospective multisite study across Subsaharan Africa, we analyzed metabolic profiles in serum and plasma from HIV-negative, TB-exposed individuals who either progressed to TB 3–24 months post-exposure (progressors) or remained healthy (controls). We generated a trans-African metabolic biosignature for TB, which identifies future progressors both on blinded test samples and in external data sets and shows a performance of 69% sensitivity at 75% specificity in samples within 5 months of diagnosis. These prognostic metabolic signatures are consistent with development of subclinical disease prior to manifestation of active TB. Metabolic changes associated with pre-symptomatic disease are observed as early as 12 months prior to TB diagnosis, thus enabling timely interventions to prevent disease progression and transmission. © 2018, The Author(s).
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC6283869/bin/41467_2018_7635_MOESM1_ESM.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC6283869/bin/41467_2018_7635_MOESM2_ESM.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC6283869/bin/41467_2018_7635_MOESM3_ESM.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC6283869/bin/41467_2018_7635_MOESM4_ESM.xlsx
Authors & Co-Authors
Weiner, January Mikolaj
Germany, Berlin
Max Planck Institute for Infection Biology
Maertzdorf, Jeroen
Germany, Berlin
Max Planck Institute for Infection Biology
Sutherland, Jayne S.
Gambia, Banjul
Medical Research Council Laboratories Gambia
Duffy, Fergal J.
United States, Seattle
Seattle Biomedical Research Institute
Thompson, Ethan G.
United States, Seattle
Seattle Biomedical Research Institute
Suliman, Sara A.
South Africa, Cape Town
University of Cape Town
McEwen, Gayle
Germany, Berlin
Max Planck Institute for Infection Biology
Germany, Berlin
Leibniz Institute for Zoo and and Wildlife Research
Thiel, Bonnie A.
United States, Cleveland
University Hospitals Case Medical Center
Parida, Shreemanta K.
Germany, Berlin
Max Planck Institute for Infection Biology
Zyla, Joanna
Germany, Berlin
Max Planck Institute for Infection Biology
Hanekom, Willem A.
South Africa, Cape Town
University of Cape Town
Mohney, Robert P.
United States, Morrisville
Metabolon, Inc.
Boom, W. Henry
United States, Cleveland
University Hospitals Case Medical Center
Mayanja-Kizza, Harriet
Uganda, Kampala
Makerere University
Howe, Rawleigh Craig
Ethiopia, Addis Ababa
Armauer Hansen Research Institute
Dockrell, Hazel M.
United Kingdom, London
London School of Hygiene & Tropical Medicine
Ottenhoff, Tom H.M.
Netherlands, Leiden
Leids Universitair Medisch Centrum
Scriba, Thomas J.
South Africa, Cape Town
University of Cape Town
Zak, Daniel E.
United States, Seattle
Seattle Biomedical Research Institute
Walzl, Gerhard
South Africa, Tygerberg
South African Medical Research Council
Kaufmann, Stefan Hugo Ernst
Germany, Berlin
Max Planck Institute for Infection Biology
Abebe, Almaz
Ethiopia, Addis Ababa
Ethiopian Public Health Institute
Abel, Brian
South Africa, Cape Town
University of Cape Town
Adegbola, Richard A.
Gambia, Banjul
Medical Research Council Laboratories Gambia
Adetifa, Ifedayo Morayo O.
Gambia, Banjul
Medical Research Council Laboratories Gambia
Ambrose, Lyn R.
Malawi, Chilumba
Malawi Epidemiology and Intervention Research Unit
Andersen, Peter Lawætz
Denmark, Copenhagen
Statens Serum Institut
Antonio, Martin
Gambia, Banjul
Medical Research Council Laboratories Gambia
Aseffa, Abraham
Ethiopia, Addis Ababa
Armauer Hansen Research Institute
van Baarle, Debbie
Netherlands, Utrecht
University Medical Center Utrecht
Barker, Lew F.
United States, Rockville
Aeras
Bekele, Yonas Y.
Ethiopia, Addis Ababa
Armauer Hansen Research Institute
Bilek, Nicole
South Africa, Cape Town
University of Cape Town
Black, Gillian Frances
South Africa, Tygerberg
South African Medical Research Council
Bowmaker, Mark
South Africa, Cape Town
University of Cape Town
Branson, Keith
Malawi, Chilumba
Malawi Epidemiology and Intervention Research Unit
Brennan, Michael James
United States, Rockville
Aeras
Chegou, Novel N.
South Africa, Tygerberg
South African Medical Research Council
Chilongo, Femia
Malawi, Chilumba
Malawi Epidemiology and Intervention Research Unit
Chung, William Kwong
South Africa, Cape Town
University of Cape Town
Corrah, Tumani P.
Gambia, Banjul
Medical Research Council Laboratories Gambia
Crampin, Amelia Catharine
Malawi, Chilumba
Malawi Epidemiology and Intervention Research Unit
Doherty, Timothy Mark
Denmark, Copenhagen
Statens Serum Institut
Dolganov, Gregory M.
United States, Palo Alto
Stanford University
Donkor, Simon A.
Gambia, Banjul
Medical Research Council Laboratories Gambia
Downing, Katrina J.
South Africa, Cape Town
University of Cape Town
Fisher, Michelle L.
South Africa, Cape Town
University of Cape Town
Franken, Kees L.M.C.
Netherlands, Leiden
Leids Universitair Medisch Centrum
French, N.
Malawi, Chilumba
Malawi Epidemiology and Intervention Research Unit
Geiter, Lawrence J.
United States, Rockville
Aeras
Geluk, Annemieke
Netherlands, Leiden
Leids Universitair Medisch Centrum
Golinski, Robert
Germany, Berlin
Max Planck Institute for Infection Biology
Gorak-Stolinska, Patricia M.A.
United Kingdom, London
London School of Hygiene & Tropical Medicine
Haks, Mariëlle C.
Netherlands, Leiden
Leids Universitair Medisch Centrum
Hill, Philip C.
Gambia, Banjul
Medical Research Council Laboratories Gambia
Hughes, Jane E.
South Africa, Cape Town
University of Cape Town
Hur, Yun-gyoung
United Kingdom, London
London School of Hygiene & Tropical Medicine
Iwnetu, Rachel
Ethiopia, Addis Ababa
Armauer Hansen Research Institute
Jacobson, Marc
Germany, Berlin
Max Planck Institute for Infection Biology
Joloba, Moses Lutaakome
Uganda, Kampala
Makerere University
Joosten, Simone A.
Netherlands, Leiden
Leids Universitair Medisch Centrum
M Kagina, Benjamin Mugo N.
South Africa, Cape Town
University of Cape Town
Kassa, Desta
Ethiopia, Addis Ababa
Ethiopian Public Health Institute
Kisingo, Hussein
Uganda, Kampala
Makerere University
Klein, Michèl R.
Netherlands, Leiden
Leids Universitair Medisch Centrum
Kriel, Magdalena
South Africa, Tygerberg
South African Medical Research Council
Lalor, Maeve K.
United Kingdom, London
London School of Hygiene & Tropical Medicine
Lee, Ji-sook
United Kingdom, London
London School of Hygiene & Tropical Medicine
Loxton, A. G.
South Africa, Tygerberg
South African Medical Research Council
Mahomed, Hassan
South Africa, Cape Town
University of Cape Town
van Meijgaarden, Krista E.
Netherlands, Leiden
Leids Universitair Medisch Centrum
Mesele, Tsehayenesh
Ethiopia, Addis Ababa
Ethiopian Public Health Institute
Miedema, Frank F.
Netherlands, Utrecht
University Medical Center Utrecht
Mihret, Adane
Ethiopia, Addis Ababa
Armauer Hansen Research Institute
Mulenga, Humphrey
South Africa, Cape Town
University of Cape Town
Muller, Stefanie
United States, Rockville
Aeras
Mvula, Hazzie
Malawi, Chilumba
Malawi Epidemiology and Intervention Research Unit
Nene, Nonhlanhla F.
South Africa, Tygerberg
South African Medical Research Council
Ngwira, Bagrey M.M.
Malawi, Chilumba
Malawi Epidemiology and Intervention Research Unit
Nsereko, Mary
Uganda, Kampala
Makerere University
Okwera, Brenda
Uganda, Kampala
Makerere University
Ota, Martin Okechukwu C.
Gambia, Banjul
Medical Research Council Laboratories Gambia
Penn-Nicholson, Adam
South Africa, Cape Town
University of Cape Town
Du Plessis, Nelita M.
South Africa, Tygerberg
South African Medical Research Council
Ramachandran, S.
United States, Rockville
Aeras
Rosenkrands, Ida
Denmark, Copenhagen
Statens Serum Institut
Sadoff, Jerald C.
United States, Rockville
Aeras
Saul, Jacky
Malawi, Chilumba
Malawi Epidemiology and Intervention Research Unit
Schoolnik, Gary K.
United States, Palo Alto
Stanford University
Simukonda, Felanji D.
Malawi, Chilumba
Malawi Epidemiology and Intervention Research Unit
Sizemore, Donata R.
United States, Rockville
Aeras
Smith, Steven G.
United Kingdom, London
London School of Hygiene & Tropical Medicine
Ben-Smith, Anne W.
Malawi, Chilumba
Malawi Epidemiology and Intervention Research Unit
Van Der Spuy, Gian D.
South Africa, Tygerberg
South African Medical Research Council
Stanley, Kim
South Africa, Tygerberg
South African Medical Research Council
Tabb, David L.
South Africa, Tygerberg
South African Medical Research Council
Tafesse, Mesfin
Ethiopia, Addis Ababa
Armauer Hansen Research Institute
Tegbaru, Belete
Ethiopia, Addis Ababa
Ethiopian Public Health Institute
Togun, Toyin Omotayo
Gambia, Banjul
Medical Research Council Laboratories Gambia
Tromp, Gerard C.
South Africa, Tygerberg
South African Medical Research Council
Van, Tran T.
United States, Palo Alto
Stanford University
Watkins, Kate
Malawi, Chilumba
Malawi Epidemiology and Intervention Research Unit
Weichold, Frank F.
United States, Rockville
Aeras
Weldingh, Karin N.
Denmark, Copenhagen
Statens Serum Institut
Yamuah, Lawrence K.
Ethiopia, Addis Ababa
Armauer Hansen Research Institute
Zalwango, Sarah K.
Uganda, Kampala
Makerere University
Statistics
Citations: 150
Authors: 106
Affiliations: 18
Identifiers
Doi:
10.1038/s41467-018-07635-7
ISSN:
20411723
Research Areas
Infectious Diseases
Noncommunicable Diseases
Study Design
Cohort Study