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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Genetic and environmental influences on total plasma homocysteine and its role in coronary artery disease risk
Atherosclerosis, Volume 222, No. 1, Year 2012
Notification
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Description
Background: Elevated levels of total plasma homocysteine are a risk factor for atherosclerotic disease. Aims: The rationale behind this study is to explore the correlation between degree and site of coronary lesion and hyperhomocysteinemia in Lebanese CAD patients and assess environmental and genetic factors for elevated levels of total plasma homocysteine. Methods: A total of 2644 patients were analyzed for traditional CAD risk factors. Logistic regression was performed to determine the association of hyperhomocysteinemia with degree and site of coronary lesions controlling for risk factors. Environmental and genetic factors for hyperhomocysteinemia were analyzed by logistic regression using a candidate gene approach. Results: Traditional risk factors were correlated with stenosis. Hyperhomocysteinemia associated with increased risk of overall stenosis, and risk of mild and severe occlusion in major arteries. Hyperhomocysteinemia and hypertension were highly correlated suggesting that hyperhomocysteinemia acts as a hypertensive agent leading to CAD. Diuretics and genetic polymorphisms in MTHFR and SLCO1B1 were associated with hyperhomocysteinemia. Conclusions: Hyperhomocysteinemia is a medical indicator of specific vessel stenosis in the Lebanese population. Hypertension is a major link between hyperhomocysteinemia and CAD occurrence. Genetic polymorphisms and diuretics' intake explain partly elevated homocysteine levels. This study has important implications in CAD risk prediction. © 2012 Elsevier Ireland Ltd.
Authors & Co-Authors
Ghassibe-Sabbagh, Michella
Lebanon, Beirut
Lebanese American University
Platt, Daniel E.
United States, Yorktown Heights
Ibm Thomas J. Watson Research Center
Youhanna, Sonia C.
Lebanon, Beirut
Lebanese American University
AbchÉE, Antoine B.
Lebanon, Beirut
American University of Beirut
Stewart, Krista
United States, Madison
University of Wisconsin-madison
BADRO, Danielle A.
Lebanon, Beirut
Lebanese American University
Haber, Marc E.
Lebanon, Beirut
Lebanese American University
Salloum, Angélique K.
Lebanon, Beirut
Lebanese American University
Douaihy, Bouchra
Lebanon, Beirut
Lebanese American University
el Bayeh, Hamid
Lebanon, Beirut
Lebanese American University
Othman, Raed
Lebanon, Beirut
Rafik Hariri University Hospital
Shasha, Nabil
Lebanon, Beirut
Rafik Hariri University Hospital
Kibbani, Samer
Lebanon, Beirut
Rafik Hariri University Hospital
Chammas, Elie J.
Lebanon, Beirut
Lebanese American University
Milane, A.
Lebanon, Beirut
Lebanese American University
Nemr, Rita
Lebanon, Beirut
Lebanese American University
Kamatani, Yoichiro
France, Paris
Fondation Jean Dausset - Ceph
Hager, Jörg
France, Evry
Centre National de Recherche en Génomique Humaine
Cazier, Jean Baptiste
United Kingdom, Oxford
The Wellcome Centre for Human Genetics
Gauguier, Dominique
United Kingdom, Oxford
The Wellcome Centre for Human Genetics
France, Paris
Centre de Recherche Des Cordeliers
Zalloua, Pierre A.
Lebanon, Beirut
Lebanese American University
United States, Boston
Harvard T.h. Chan School of Public Health
Statistics
Citations: 34
Authors: 21
Affiliations: 10
Identifiers
Doi:
10.1016/j.atherosclerosis.2012.02.035
e-ISSN:
18791484
Research Areas
Genetics And Genomics
Noncommunicable Diseases
Study Design
Cross Sectional Study