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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Quince (Cydonia oblonga Miller) peel polyphenols modulate LPS-induced inflammation in human THP-1-derived macrophages through NF-κB, p38MAPK and Akt inhibition
Biochemical and Biophysical Research Communications, Volume 418, No. 1, Year 2012
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Description
Chronic inflammation is a hallmark of several pathologies, such as rheumatoid arthritis, gastritis, inflammatory bowel disease, atherosclerosis and cancer. A wide range of anti-inflammatory chemicals have been used to treat such diseases while presenting high toxicity and numerous side effects. Here, we report the anti-inflammatory effect of a non-toxic, cost-effective natural agent, polyphenolic extract from the Tunisian quince Cydonia oblonga Miller. Lipopolysaccharide (LPS) treatment of human THP-1-derived macrophages induced the secretion of high levels of the pro-inflammatory cytokine TNF-α and the chemokine IL-8, which was inhibited by quince peel polyphenolic extract in a dose-dependent manner. Concomitantly, quince polyphenols enhanced the level of the anti-inflammatory cytokine IL-10 secreted by LPS-treated macrophages. We further demonstrated that the unexpected increase in IL-6 secretion that occurred when quince polyphenols were associated with LPS treatment was partially responsible for the polyphenols-mediated inhibition of TNF-α secretion. Biochemical analysis showed that quince polyphenols extract inhibited the LPS-mediated activation of three major cellular pro-inflammatory effectors, nuclear factor-kappa B (NF-κB), p38MAPK and Akt. Overall, our data indicate that quince peel polyphenolic extract induces a potent anti-inflammatory effect that may prove useful for the treatment of inflammatory diseases and that a quince-rich regimen may help to prevent and improve the treatment of such diseases. © 2012 Elsevier Inc.
Authors & Co-Authors
Essafi-Benkhadir, Khadija
Tunisia, Tunis
Institut Pasteur de Tunis
Refai, Amira
Tunisia, Tunis
Institut Pasteur de Tunis
Riahi, Ichrak
Tunisia, Tunis
Institut Pasteur de Tunis
Fattouch, Sami
Tunisia, Tunis
University of Carthage, Institut National Des Sciences Appliquées et de Technologie
Karoui, Habib
Tunisia, Tunis
Institut Pasteur de Tunis
Essafi, Makram
Tunisia, Tunis
Institut Pasteur de Tunis
Statistics
Citations: 94
Authors: 6
Affiliations: 2
Identifiers
Doi:
10.1016/j.bbrc.2012.01.003
ISSN:
0006291X
e-ISSN:
10902104
Research Areas
Cancer
Environmental