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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
CCL3L1 copy number, HIV load, and immune reconstitution in sub-Saharan Africans
BMC Infectious Diseases, Volume 13, No. 1, Article 536, Year 2013
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Description
Background: The role of copy number variation of the CCL3L1 gene, encoding MIP1α, in contributing to the host variation in susceptibility and response to HIV infection is controversial. Here we analyse a sub-Saharan African cohort from Tanzania and Ethiopia, two countries with a high prevalence of HIV-1 and a high co-morbidity of HIV with tuberculosis.Methods: We use a form of quantitative PCR called the paralogue ratio test to determine CCL3L1 gene copy number in 1134 individuals and validate our copy number typing using array comparative genomic hybridisation and fiber-FISH.Results: We find no significant association of CCL3L1 gene copy number with HIV load in antiretroviral-naïve patients prior to initiation of combination highly active anti-retroviral therapy. However, we find a significant association of low CCL3L1 gene copy number with improved immune reconstitution following initiation of highly active anti-retroviral therapy (p = 0.012), replicating a previous study.Conclusions: Our work supports a role for CCL3L1 copy number in immune reconstitution following antiretroviral therapy in HIV, and suggests that the MIP1α -CCR5 axis might be targeted to aid immune reconstitution. © 2013 Aklillu et al.; licensee BioMed Central Ltd.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC3829100/bin/1471-2334-13-536-S1.doc
https://efashare.b-cdn.net/share/pmc/articles/PMC3829100/bin/1471-2334-13-536-S2.doc
https://efashare.b-cdn.net/share/pmc/articles/PMC3829100/bin/1471-2334-13-536-S3.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC3829100/bin/1471-2334-13-536-S4.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC3829100/bin/1471-2334-13-536-S5.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC3829100/bin/1471-2334-13-536-S6.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC3829100/bin/1471-2334-13-536-S7.pdf
Authors & Co-Authors
Aklillu, Eleni
Sweden, Stockholm
Karolinska Institutet
Odenthal-Hesse, Linda
United Kingdom, Leicester
University of Leicester
Bowdrey, Jennifer
United Kingdom, Leicester
University of Leicester
Habtewold, Abiy
Sweden, Stockholm
Karolinska Institutet
Ethiopia, Addis Ababa
Addis Ababa University
Ngaimisi, Eliford
Sweden, Stockholm
Karolinska Institutet
Tanzania, Dar es Salaam
Muhimbili University of Health and Allied Sciences
Yimer, Getnet
Sweden, Stockholm
Karolinska Institutet
Ethiopia, Addis Ababa
Addis Ababa University
Amogne, Wondwossen
Ethiopia, Addis Ababa
Addis Ababa University
Sweden, Stockholm
Karolinska Universitetssjukhuset
Mugusi, Sabina Ferdinand
Tanzania, Dar es Salaam
Muhimbili National Hospital
Minzi, Omary Mashiku Sylivester
Tanzania, Dar es Salaam
Muhimbili University of Health and Allied Sciences
Makonnen, Eyasu
Ethiopia, Addis Ababa
Addis Ababa University
Janabi, Mohamed Y.
Tanzania, Dar es Salaam
Muhimbili University of Health and Allied Sciences
Mugusi, Ferdinand M.
Tanzania, Dar es Salaam
Muhimbili University of Health and Allied Sciences
Aderaye, Getachew
Ethiopia, Addis Ababa
Addis Ababa University
Hardwick, Robert J.
United Kingdom, Leicester
University of Leicester
Fu, Beiyuan
United Kingdom, Hinxton
Wellcome Sanger Institute
Viskaduraki, Maria
United Kingdom, Leicester
University of Leicester
Yang, Fengtang
United Kingdom, Hinxton
Wellcome Sanger Institute
Hollox, Edward J.
United Kingdom, Leicester
University of Leicester
Statistics
Citations: 26
Authors: 18
Affiliations: 7
Identifiers
Doi:
10.1186/1471-2334-13-536
e-ISSN:
14712334
Research Areas
Genetics And Genomics
Infectious Diseases
Study Design
Cross Sectional Study
Cohort Study
Study Approach
Quantitative
Study Locations
Ethiopia
Tanzania