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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Increased levels of autoantibodies against catalase and superoxide dismutase associated with oxidative stress in patients with rheumatoid arthritis and systemic lupus erythematosus
Scandinavian Journal of Rheumatology, Volume 37, No. 2, Year 2008
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Description
Objective: To evaluate the level of autoantibodies against superoxide dismutase (SOD) and catalase (CAT) in the sera of rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) Tunisian patients, to study the oxidative profile among the same patients and to establish a correlation between the two parameters in order to understand the role of each one in the genesis of the two diseases. Method: Using a standard enzyme-linked immunosorbent assay (ELISA), the levels of immunoglobulin G (IgG) and IgM directed against CAT and SOD in the sera of 39 RA patients, 40 SLE patients, and 50 control healthy individuals were evaluated. The oxidative/antioxidative profile was tested by measuring serum malondialdehyde (MDA), conjugated dienes (CD), CAT activity, and SOD activity. Results: Our data showed increased levels of IgG antibodies (Ab) against CAT in both groups of patients (p<0.05) compared to control subjects. However, the SLE patients displayed an increased level of anti-SOD IgG (p<0.05). In all patients the lipid peroxidation was confirmed by high levels of MDA and conjugated dienes (p<0.05). RA patients exhibited an increasing CAT and SOD activity in their sera (p<0.05) with a positive correlation observed between CAT and IgG anti-CAT (p<0.05). The same results were observed for SLE patients. In addition, a positive correlation was observed between anti-CAT Ab and anti-SOD Ab in SLE patients (p<0.05). Conclusion: Collectively, these results suggested that the primary factor causing the oxidative stress observed in RA and SLE is excessive free radical production rather than impaired CAT or SOD activity due to autoantibody inhibition. © 2008 Taylor & Francis on license from Scandinavian Rheumatology Research Foundation.
Authors & Co-Authors
Ben Mansour, Riadh
Tunisia, Sfax
Higher Institute of Biotechnology of Sfax Isbs
Lassoued, Saloua
Tunisia, Sfax
Higher Institute of Biotechnology of Sfax Isbs
Gargouri, Bochra
Tunisia, Sfax
Higher Institute of Biotechnology of Sfax Isbs
Gaïd, A. El
Tunisia, Sfax
Higher Institute of Biotechnology of Sfax Isbs
Attia, Hamadi
Tunisia, Sfax
Higher Institute of Biotechnology of Sfax Isbs
Fakhfakh, Faiza
Tunisia, Sfax
Faculty of Medicine of Sfax
Statistics
Citations: 94
Authors: 6
Affiliations: 2
Identifiers
Doi:
10.1080/03009740701772465
ISSN:
03009742
e-ISSN:
15027732