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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
Widespread recombination in published animal mtDNA sequences
Molecular Biology and Evolution, Volume 22, No. 4, Year 2005
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Description
Mitochondrial DNA (mtDNA) recombination has been observed in several animal species, but there are doubts as to whether it is common or only occurs under special circumstances. Animal mtDNA sequences retrieved from public databases were unambiguously aligned and rigorously tested for evidence of recombination. At least 30 recombination events were detected among 186 alignments examined. Recombinant sequences were found in invertebrates and vertebrates, including primates. It appears that mtDNA recombination may occur regularly in the animal cell but rarely produces new haplotypes because of homoplasmy. Common animal mtDNA recombination would necessitate a reexamination of phylogenetic and biohistorical inference based on the assumption of clonal mtDNA transmission. Recombination may also have an important role in producing and purging mtDNA mutations and thus in mtDNA-based diseases and senescence. © Society for Molecular Biology and Evolution 2005; all rights reserved.
Authors & Co-Authors
Tsaousis, A. D.
Greece, Rethymnon
University of Crete
Martin, Darren Patrick
South Africa, Cape Town
University of Cape Town
Ladoukakis, E. D.
Greece, Rethymnon
University of Crete
United Kingdom, Brighton
University of Sussex
Posada, D.
Spain, Vigo
Universidade de Vigo
Zouros, E.
Greece, Rethymnon
University of Crete
Statistics
Citations: 172
Authors: 5
Affiliations: 4
Identifiers
Doi:
10.1093/molbev/msi084
ISSN:
07374038
Research Areas
Genetics And Genomics