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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
The ABCs of viral hepatitis that define biomarker signatures of acute viral hepatitis
Hepatology, Volume 59, No. 4, Year 2014
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Description
Viral hepatitis is the leading cause of liver disease worldwide and can be caused by several agents, including hepatitis A (HAV), B (HBV), and C (HCV) virus. We employed multiplexed protein immune assays to identify biomarker signatures of viral hepatitis in order to define unique and common responses for three different acute viral infections of the liver. We performed multianalyte profiling, measuring the concentrations of 182 serum proteins obtained from acute HAV- (18), HBV- (18), and HCV-infected (28) individuals, recruited as part of a hospital-based surveillance program in Cairo, Egypt. Virus-specific biomarker signatures were identified and validation was performed using a unique patient population. A core signature of 46 plasma proteins was commonly modulated in all three infections, as compared to healthy controls. Principle component analysis (PCA) revealed a host response based upon 34 proteins, which could distinguish HCV patients from HAV- and HBV-infected individuals or healthy controls. When HAV and HBV groups were compared directly, 34 differentially expressed serum proteins allowed the separation of these two patient groups. A validation study was performed on an additional 111 patients, confirming the relevance of our initial findings, and defining the 17 analytes that reproducibly segregated the patient populations. Conclusions: This combined discovery and biomarker validation approach revealed a previously unrecognized virus-specific induction of host proteins. The identification of hepatitis virus specific signatures provides a foundation for functional studies and the identification of potential correlates of viral clearance. © 2014 by the American Association for the Study of Liver Diseases.
Authors & Co-Authors
Duffy, Darragh
France, Paris
Institut Pasteur, Paris
France, Paris
Inserm
Mamdouh, Rasha
Egypt, Cairo
Faculty of Medicine - Ain Shams University
Laird, Melissa E.
France, Paris
Institut Pasteur, Paris
France, Paris
Inserm
Soneson, Charlotte
Sweden, Lund
Lunds Universitet
Le-Fouler, Lénaïg
France, Paris
Institut Pasteur, Paris
El-Daly, Maï Mohamed
Egypt, Cairo
National Hepatology and Tropical Medicine Research Institute
Egypt, Shibin el Kom
Menoufia University
Casrouge, Armanda
France, Paris
Institut Pasteur, Paris
France, Paris
Inserm
Decalf, Jérémie
France, Paris
Institut Pasteur, Paris
France, Paris
Inserm
Abbas, Amal Ahmed
Egypt, Cairo
Faculty of Medicine - Ain Shams University
Eldin, Noha Sharaf
Egypt, Cairo
Faculty of Medicine - Ain Shams University
Fontes, Magnus
Sweden, Lund
Lunds Universitet
Abdel-Hamid, Mohamed A.
Egypt, Cairo
National Hepatology and Tropical Medicine Research Institute
Egypt, Minya
Faculty of Medicine
Mohamed, Mostafa K.
Egypt, Cairo
Faculty of Medicine - Ain Shams University
Egypt, Cairo
National Hepatology and Tropical Medicine Research Institute
Rafik, Mona M.
Egypt, Cairo
Faculty of Medicine - Ain Shams University
Fontanet, A. L.
France, Paris
Institut Pasteur, Paris
France, Paris
Conservatoire National Des Arts et Metiers
Albert, Matthew L.
France, Paris
Institut Pasteur, Paris
France, Paris
Inserm
France, Paris
Université Paris Cité
Statistics
Citations: 19
Authors: 16
Affiliations: 9
Identifiers
Doi:
10.1002/hep.26901
ISSN:
02709139
Research Areas
Health System And Policy
Infectious Diseases
Study Design
Cross Sectional Study
Study Locations
Egypt