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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Neuroimaging markers of human immunodeficiency virus infection in South Africa
Journal of NeuroVirology, Volume 18, No. 3, Year 2012
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Description
Previous studies have reported cognitive deficits among HIV-positive individuals infected with clade C virus. However, no study has examined whether individuals predominately infected with clade C virus exhibit brain atrophy relative to healthy controls. This study examined volumetric differences between 28 HIV+ individuals and 23 HIV? controls from South Africa. Volumetric measures were obtained from six regions of interest - caudate, thalamus, corpus callosum, total cortex, total gray matter, and total white matter. HIV+ participants had significantly lower volumes in the total white matter (p<0.01), thalamus (p<0.01) and total gray matter (inclusive of cortical and subcortical regions, p<0.01). This study is the first to provide evidence of brain atrophy among HIV+ individuals in South Africa, where HIV clade C predominates. Additional research that integrates neuroimaging, comprehensive neuropsychological testing, genetic variance in clade-specific proteins, and the impact of treatment with Antiretrovirals (ARV) are necessary to understand the development of HIV-related neurocognitive disorders in South Africa. © Journal of NeuroVirology, Inc. 2012.
Authors & Co-Authors
Heaps, Jodi
United States, St. Louis
University of Missouri-st. Louis
Joska, John A.
South Africa, Cape Town
University of Cape Town
Hoare, Jacqueline
South Africa, Cape Town
University of Cape Town
Ortega, Mario
United States, St. Louis
Washington University School of Medicine in St. Louis
Agrawa, Aleena
United States, St. Louis
Washington University School of Medicine in St. Louis
Seedat, Soraya
South Africa, Stellenbosch
Stellenbosch University
Ances, Beau M.
United States, St. Louis
Washington University School of Medicine in St. Louis
Stein, Dan J.
South Africa, Cape Town
University of Cape Town
Paul, Robert H.
United States, St. Louis
University of Missouri-st. Louis
Statistics
Citations: 34
Authors: 9
Affiliations: 4
Identifiers
Doi:
10.1007/s13365-012-0090-5
ISSN:
13550284
e-ISSN:
15382443
Research Areas
Genetics And Genomics
Infectious Diseases
Mental Health
Study Locations
South Africa