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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
EpCAM expression is an indicator of recurrence in basal-like breast cancer
Breast Cancer Research and Treatment, Volume 133, No. 2, Year 2012
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Description
Advances in the understanding of the molecular basis of breast cancer have necessitated a definition of more sensitive and specific indicators of prognosis that are central to the underlying cancer biology and that reflect the complicated and heterogeneous nature of the disease. This study investigates the expression of epithelial cell adhesion molecule (EpCAM) in breast cancer particularly basal-like phenotype group which remains unclear. EpCAM expression was assessed using immunohistochemistry in a large well-characterised series of breast carcinomas prepared as tissue microarrays. Relationships between EpCAM expression with molecular subtypes, clinicopathological variables and patients' outcome were examined. EpCAM expression was associated with higher tumour grade (P < 0.001), larger tumour size (P < 0.001) and basal phenotype (P = 0.03). Importantly, within the basal-like tumours those positive for EpCAM showed a significantly shorter DFI (LR = 7.97, P = 0.005) and MFS (LR 4.01, P = 0.045). EpCAM may play a role in breast cancer progression and its expression is associated with poor patient outcome in basal-like breast cancer, independent of other prognostic factors. © 2012 Springer Science+Business Media, LLC.
Authors & Co-Authors
Agboola, Ayodeji O.J.
United Kingdom, Nottingham
University of Nottingham
Nigeria, Ago-iwoye
Olabisi Onabanjo University
Paish, Emma Claire
United Kingdom, Nottingham
University of Nottingham
Rakha, Emad A.
United Kingdom, Nottingham
University of Nottingham
Powe, Desmond George
United Kingdom, Nottingham
University of Nottingham
MacMillan, Robert Douglas
United Kingdom, Nottingham
Nottingham University Hospitals Nhs Trust
Ellis, Ian O.
United Kingdom, Nottingham
University of Nottingham
Green, Andew R.
United Kingdom, Nottingham
University of Nottingham
Statistics
Citations: 27
Authors: 7
Affiliations: 3
Identifiers
Doi:
10.1007/s10549-011-1813-7
ISSN:
01676806
e-ISSN:
15737217
Research Areas
Cancer
Health System And Policy