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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
general
Global monitoring of antimicrobial resistance based on metagenomics analyses of urban sewage
Nature Communications, Volume 10, No. 1, Article 1124, Year 2019
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Description
Antimicrobial resistance (AMR) is a serious threat to global public health, but obtaining representative data on AMR for healthy human populations is difficult. Here, we use metagenomic analysis of untreated sewage to characterize the bacterial resistome from 79 sites in 60 countries. We find systematic differences in abundance and diversity of AMR genes between Europe/North-America/Oceania and Africa/Asia/South-America. Antimicrobial use data and bacterial taxonomy only explains a minor part of the AMR variation that we observe. We find no evidence for cross-selection between antimicrobial classes, or for effect of air travel between sites. However, AMR gene abundance strongly correlates with socio-economic, health and environmental factors, which we use to predict AMR gene abundances in all countries in the world. Our findings suggest that global AMR gene diversity and abundance vary by region, and that improving sanitation and health could potentially limit the global burden of AMR. We propose metagenomic analysis of sewage as an ethically acceptable and economically feasible approach for continuous global surveillance and prediction of AMR. © 2019, The Author(s).
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC6408512/bin/41467_2019_8853_MOESM1_ESM.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC6408512/bin/41467_2019_8853_MOESM2_ESM.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC6408512/bin/41467_2019_8853_MOESM3_ESM.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC6408512/bin/41467_2019_8853_MOESM4_ESM.txt
https://efashare.b-cdn.net/share/pmc/articles/PMC6408512/bin/41467_2019_8853_MOESM5_ESM.xls
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https://efashare.b-cdn.net/share/pmc/articles/PMC6408512/bin/41467_2019_8853_MOESM11_ESM.pdf
Authors & Co-Authors
Hendriksen, Rene Sjøgren
Denmark, Lyngby
Technical University of Denmark
Munk, Patrick
Denmark, Lyngby
Technical University of Denmark
Njage, Patrick Murigu Kamau
Denmark, Lyngby
Technical University of Denmark
van Bunnik, Bram A.D.
United Kingdom, Edinburgh
The University of Edinburgh
McNally, Luke
United Kingdom, Edinburgh
The University of Edinburgh
Lukjancenko, Oksana
Denmark, Lyngby
Technical University of Denmark
Röder, Timo
Denmark, Lyngby
Technical University of Denmark
Nieuwenhuijse, David F.
Netherlands, Rotterdam
Erasmus Mc
Karlsmose, Susanne Karlsmose
Denmark, Lyngby
Technical University of Denmark
Kjeldgaard, Jette Sejer
Denmark, Lyngby
Technical University of Denmark
Kaas, Rolf Sommer
Denmark, Lyngby
Technical University of Denmark
Clausen, Philip Thomas Lanken Conradsen
Denmark, Lyngby
Technical University of Denmark
Vogt, Josef Korbinian
Denmark, Lyngby
Technical University of Denmark
Leekitcharoenphon, Pimlapas
Denmark, Lyngby
Technical University of Denmark
van de Schans, Milou G.M.
Netherlands, Wageningen
Wageningen University & Research
Zuidema, Tina
Netherlands, Wageningen
Wageningen University & Research
de Roda-Husman, Ana Maria
Netherlands, Bilthoven
Rijksinstituut Voor Volksgezondheid en Milieu
Rasmussen, S. B.
Denmark, Lyngby
Technical University of Denmark
Petersen, Bent
Denmark, Lyngby
Technical University of Denmark
Bego, Artan
Unknown Affiliation
Rees, Catherine A.
Australia, Melbourne
Melbourne Water Corporation
Cassar, Susan
Australia, Melbourne
Melbourne Water Corporation
Coventry, Kris
Australia, Melbourne
Melbourne Water Corporation
Collignon, Peter J.
Australia, Canberra
Canberra Hospital
Allerberger, Franz J.
Austria, Vienna
Austrian Agency for Health and Food Safety
Rahube, Teddie O.
Botswana, Palapye
Botswana International University of Science and Technology
Oliveira, Guilherme Corrêa De
Brazil, Ouro Preto
Instituto Tecnológico Vale
Ivanov, Ivan Nikolaev
Bulgaria, Sofia
National Center of Infectious and Parasitic Diseases Bulgaria
Vuthy, Yith
Cambodia, Phnom Penh
Institut Pasteur du Cambodge
Sopheak, Thet
Cambodia, Phnom Penh
Institut Pasteur du Cambodge
Yost, Christopher Karl
Canada, Regina
University of Regina
Ke, Changwen
China, Guangzhou
Guangdong Center for Disease Control and Prevention
Zheng, Huanying
China, Guangzhou
Guangdong Center for Disease Control and Prevention
Baisheng, Li
China, Guangzhou
Guangdong Center for Disease Control and Prevention
Jiao, Xiaoyang
China, Shantou
Shantou University Medical College
Donado-Godoy, Pilar
Colombia, Bogota
Corporación Colombiana de Investigación Agropecuaria, Agrosavia
Coulibaly, Kalpy Julien
Cote D'ivoire, Abidjan
Institut Pasteur de Cote-d'ivoire
Jergović, Matijana
Croatia, Zagreb
Zagreb Institute of Public Health
Hrenović, Jasna J. J.
Croatia, Zagreb
University of Zagreb
Karpíšková, Renáta
Czech Republic, Brno
Veterinary Research Institute, Brno
Villacis, Jose Eduardo
Unknown Affiliation
Legesse, Mengistu
Ethiopia, Addis Ababa
Addis Ababa University
Eguale, Tadesse
Ethiopia, Addis Ababa
Addis Ababa University
Heikinheimo, Annamari
Finland, Helsinki
Helsingin Yliopisto
Malania, Lile
Georgia, Tbilisi
National Center for Disease Control and Public Health
Nitsche, Andreas
Germany, Berlin
Robert Koch Institute
Brinkmann, Annika
Germany, Berlin
Robert Koch Institute
Saba, Courage Kosi Setsoafia
Ghana, Tamale
University for Development Studies Ghana
Kocsis, Béla
Hungary, Budapest
Semmelweis Egyetem
Solymosi, Norbert
Hungary, Budapest
University of Veterinary Medicine Budapest
Thorsteinsdottir, Thorunn Rafnar
Iceland, Reykjavik
Haskoli Islands
Mohamed Hatha, Abdulla
India, Kochi
Cochin University of Science and Technology
Alebouyeh, Masoud
Iran, Tehran
Shahid Beheshti University of Medical Sciences
Morris, Dearbháile
Ireland, Galway
University of Galway
Cormican, Martin G.M.
Ireland, Galway
University of Galway
O’Connor, Louise
Ireland, Galway
University of Galway
Moran-Gilad, Jacob
Israel, Beer-sheva
Ben-gurion University of the Negev
Alba, Patricia
Italy, Rome
Istituto Zooprofilattico Sperimentale Delle Regioni Lazio e Toscana
Battisti, Antonio
Italy, Rome
Istituto Zooprofilattico Sperimentale Delle Regioni Lazio e Toscana
Shakenova, Zeinegul
Unknown Affiliation
Kiiyukia, Ciira
Kenya, Thika
Mount Kenya University
Ng’eno, Eric
Kenya, Nairobi
Kenya Medical Research Institute
Raka, Lul
Serbia, Pristina
National Institute of Public Health of Kosovo
Avsejenko, Jelena
Latvia, Riga
Institute of Food Safety, Animal Health and Environment - Bior
Berzins, Aivars
Latvia, Riga
Institute of Food Safety, Animal Health and Environment - Bior
Bartkevics, Vadims
Latvia, Riga
Institute of Food Safety, Animal Health and Environment - Bior
Penny, Christian
Luxembourg, Esch-sur-alzette
Luxembourg Institute of Science and Technology
Heera, Rajandas
Unknown Affiliation
Parimannan, Sivachandran
Unknown Affiliation
Haber, Malcolm Vella
Unknown Affiliation
Pal, Pushkar
New Zealand, Dunedin
University of Otago
Jeunen, Gert Jan
Nigeria, Ibadan
University of Ibadan
Gemmell, Neil J.
Nigeria, Ibadan
University of Ibadan
Fashae, Kayode F.
Unknown Affiliation
Holmstad, Rune
Pakistan, Karachi
The Aga Khan University
Hasan, Rumina S.
United States, Bethesda
National Institutes of Health Nih
Shakoor’, Sadia
United States, Bethesda
National Institutes of Health Nih
Rojas, Maria Luz Zamudio
Poland, Pulawy
Państwowy Instytut Weterynaryjny - Państwowy Instytut Badawczy
Wasyl, Dariusz
North Macedonia, Skopje
Institute of Public Health of the Republic of North Macedonia
Bosevska, Golubinka
Moldova, Chisinau
Nicolae Testemitanu State University of Medicine and Pharmacy
Kochubovski, Mihail V.
Moldova, Chisinau
Nicolae Testemitanu State University of Medicine and Pharmacy
Radu, Cojocaru
Senegal, Dakar
Institut Pasteur de Dakar
Gassama, Amy
Serbia, Belgrade
University of Belgrade Faculty of Veterinary Medicine
Radosavljević, Vladimir I.
Singapore, Singapore City
Singapore Centre for Environmental Life Sciences Engineering
Wuertz, Stefan
Singapore, Singapore City
Nanyang Technological University
Zuniga-Montanez, Rogelio E.
Singapore, Singapore City
Nanyang Technological University
Tay, Moon Yue Feng
Slovakia, Bratislava
Public Health Authority of the Slovak Republic
Gavačová, Dagmar
Unknown Affiliation
Pastuchová, Katarína
Unknown Affiliation
Truska, Peter
Unknown Affiliation
Trkov, Marija
South Africa, Pretoria
Daspoort Waste Water Treatment Works
Esterhuyse, Kerneels
South Africa, Johannesburg
University of the Witwatersrand
Keddy, Karen Helena
Spain, Cerdanyola Del Valles
Universitat Autònoma de Barcelona
Cerdà-Cuèllar, Marta
Unknown Affiliation
Pathirage, Sujatha
Sweden, Uppsala
Sveriges Lantbruksuniversitet
Norrgren, Leif
Sweden, Gothenburg
Göteborgs Universitet
Örn, Stefan
Sweden, Gothenburg
Göteborgs Universitet
Larsson, D. G.Joakim
Unknown Affiliation
Heijden, Tanja Van Der
Tanzania, Moshi
Kilimanjaro Clinical Research Institute
Kumburu, Happiness Houka
Gambia, Banjul
Ministry of Health and Social Welfare
Sanneh, Bakary
Togo, Lome
National Institute of Hygiene
Bidjada, Pawou
Togo, Lome
Agence de Médecine Préventive
Njanpop-Lafourcade, Berthe Marie
Unknown Affiliation
Nikiema-Pessinaba, Somtinda Christelle
Unknown Affiliation
Levent, Belkıs
United States, Seattle
University of Washington
Meschke, John Scott
Viet Nam, Ho Chi Minh City
Institute of Public Health in ho Chi Minh City
Beck, Nicola Koren
Viet Nam, Ho Chi Minh City
Institute of Public Health in ho Chi Minh City
Kwenda, Geoffrey
Chad, N'djamena
University of N’djamena
Tabo, Djim Adjim
Norway, Oslo
Folkehelseinstituttet
Wester, Astrid Louise
Switzerland, Geneva
Organisation Mondiale de la Santé
Chile, Talca
Universidad Católica Del Maule
Cuadros-Orellana, Sara
Chile, Talca
Universidad Católica Del Maule
Amid, Clara
United Kingdom, Hinxton
European Molecular Biology Laboratory
Cochrane, Guy R.
United Kingdom, Hinxton
European Molecular Biology Laboratory
Sicheritz-Pontén, Thomas E.
Unknown Affiliation
Schmitt, Heike
Netherlands, Bilthoven
Rijksinstituut Voor Volksgezondheid en Milieu
Aïdara-Kane, Awa
Switzerland, Geneva
Organisation Mondiale de la Santé
Pamp, Sünje Johanna
Denmark, Lyngby
Technical University of Denmark
Lund, Ole Sogaard
Denmark, Lyngby
Technical University of Denmark
Hald, Tine
Denmark, Lyngby
Technical University of Denmark
Woolhouse, Mark E.J.
United Kingdom, Edinburgh
The University of Edinburgh
Koopmans, Marion P.G.
Netherlands, Rotterdam
Erasmus Mc
Vigre, Håkan
Denmark, Lyngby
Technical University of Denmark
Petersen, Thomas Nordahl
Denmark, Lyngby
Technical University of Denmark
Aarestrup, Frank Møller
Denmark, Lyngby
Technical University of Denmark
Statistics
Citations: 560
Authors: 124
Affiliations: 67
Identifiers
Doi:
10.1038/s41467-019-08853-3
ISSN:
20411723
Research Areas
Environmental
Genetics And Genomics