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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Prevalence and factors associated with rotavirus infection among children admitted with acute diarrhea in Uganda
BMC Pediatrics, Volume 10, Article 69, Year 2010
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Description
Background: Rotavirus remains the commonest cause of severe dehydrating diarrhea among children worldwide. Children in developing countries die more because of several factors including poorer access to hydration therapy and greater prevalence of malnutrition. Hitherto, the magnitude of rotavirus disease in Uganda has remained unknown. This study was therefore done to determine the prevalence and factors associated with rotavirus infection among children aged 3-59 months admitted with acute diarrhea to paediatric emergency ward of Mulago Hospital, Uganda. Methods: Three hundred and ninety children, aged between 3-59 months with acute diarrhoea were recruited. The clinical history, socio-demographic characteristics, physical examination findings and laboratory investigations were recorded. Stool samples were tested for rotavirus antigens using the DAKO IDEIA rotavirus EIA detection kit.Results: The prevalence of rotavirus infection was 45.4%. On multivariate analysis rotavirus was significantly associated with a higher education (above secondary) level of the mother [OR 1.8; 95% CI 1.1-2.7]; dehydration [OR 1.8; 95% CI 1.1-3.0] and breastfeeding [OR 2.6; 95% CI 1.4-4.0]. Although age was significantly associated with rotavirus on bivariate analysis; this association disappeared on multivariate analysis. No significant association was found between rotavirus infection and nutritional status, HIV status and attendance of day care or school.Conclusions: Rotavirus infection is highly prevalent among children with acute diarrhoea admitted to Mulago Hospital in Uganda. © 2010 Nakawesi et al; licensee BioMed Central Ltd.
Authors & Co-Authors
Nakawesi, Jane S.
Uganda, Kampala
Makerere University College of Health Sciences
Wobudeya, Eric
Uganda, Kampala
Mulago National Referral Hospital
Ndeezi, Grace
Uganda, Kampala
Makerere University College of Health Sciences
Mworozi, Edison Arwanire
Uganda, Kampala
Mulago National Referral Hospital
Tumwine, James Kashugyera
Uganda, Kampala
Makerere University College of Health Sciences
Statistics
Citations: 90
Authors: 5
Affiliations: 2
Identifiers
Doi:
10.1186/1471-2431-10-69
e-ISSN:
14712431
Research Areas
Food Security
Health System And Policy
Infectious Diseases
Maternal And Child Health
Study Design
Cross Sectional Study
Study Locations
Uganda