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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Adherence to antiretroviral therapy, virologic failure and workload at the Rustenburg Provincial Hospital
South African Family Practice, Volume 52, No. 4, Year 2010
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Description
Background: Adherence to antiretroviral therapy (ART) is a strong predictor of progression to AIDS and death. It remains the most important potentially alterable factor that determines treatment outcomes. Methods: The study is a cross-sectional survey of self-reported adherence to ART and associated factors. It included a randomly selected sample of 100 adult patients who began ART between June 2006 and December 2007. A modified Adult AIDS Clinical Trials Group questionnaire was used. The analysis compared self-reported adherence levels by factor and viral load test results. Results: Only 71% of patients had an adherence > 95%. Poor adherence was related to changes in daily routines (being away from home [21%] and busy with other things [17%]). All patients with symptoms suggestive of clinical depression had virologic failure. More unemployed patients (50.7%) had virologic failure than did employed patients (40%) (p = < 0.05). The clinic had a tenfold increase in patient enrolment and a ninefold decline in staff-to-patient ratio, and the proportion of patients lost to follow-up doubled in the preceding four years. Conclusion: Adherence to ART was poor. The capacity of the clinic to manage patients adequately has declined significantly. Decentralisation of ART services to primary health care facilities should be considered. © SAAFP.
Authors & Co-Authors
Chabikuli, Nzapfurundi Otto
Nigeria, Gha
Global Hiv/aids Initiative Nigeria Ghain
South Africa, Pretoria
University of Pretoria
Datonye, D. O.
South Africa, Pretoria
University of Pretoria
Nachega, J. B.
South Africa, Stellenbosch
Stellenbosch University
Ansong, Daniel Ayirebi
Ghana
Kwameh Nkrumah University of Science and Technology
Statistics
Citations: 16
Authors: 4
Affiliations: 4
Identifiers
Doi:
10.1080/20786204.2010.10874005
e-ISSN:
20786204
Research Areas
Health System And Policy
Infectious Diseases
Mental Health
Study Design
Cross Sectional Study
Cohort Study
Study Approach
Quantitative