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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Identification of o-quinone/quinone methide metabolites of quercetin in a cellular in vitro system
FEBS Letters, Volume 520, No. 1-3, Article 26110, Year 2002
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Description
Formation of quercetin quinone/quinone methide metabolites, reflected by formation of the glutathionyl quercetin adducts as authentic metabolites, was investigated in an in vitro cell model (B16F-10 melanoma cells). Results of the present study clearly indicate the formation of glutathionyl quercetin adducts in a tyrosinase-containing melanoma cell line, expected to be representative also for peroxidase-containing mammalian cells and tissues. The data obtained also support that the adducts are formed intracellular and subsequently excreted into the incubation medium and reveal for the first time evidence for the pro-oxidative metabolism of quercetin in a cellular in vitro model. © 2002 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.
Authors & Co-Authors
Awad, Hanem M.
Netherlands, Wageningen
Wageningen University & Research
Boersma, Marelle G.
Netherlands, Wageningen
Wageningen University & Research
Boeren, Sjef A.
Netherlands, Wageningen
Wageningen University & Research
Vervoort, Jacques J.M.
Netherlands, Wageningen
Wageningen University & Research
Rietjens, Ivonne M.C.M.
Netherlands, Wageningen
Wageningen University & Research
Statistics
Citations: 101
Authors: 5
Affiliations: 2
Identifiers
Doi:
10.1016/S0014-5793(02)02754-0
ISSN:
00145793