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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Time to and predictors of CD4+ T-lymphocytes recovery in HIV-infected children initiating highly active antiretroviral therapy in Ghana
AIDS Research and Treatment, Volume 2011, Article 896040, Year 2011
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Description
Background. CD4+ T-lymphocyte monitoring is not routinely available in most resource-limited settings. We investigated predictors of time to CD4+ T-lymphocyte recovery in HIV-infected children on highly active antiretroviral (HAART) at Korle-Bu Teaching Hospital, Ghana. Methods. Time to CD4+ T-lymphocyte recovery was defined as achieving percent CD4+ T-lymphocytes of 25%. We used Cox proportional hazard models for identifying significant predictor variables. Results. Of the 233 children with complete CD4+ T-lymphocyte data, the mean age at HAART initiation was 5.5 (SD=3.1) years. The median recovery time was 60 weeks (95% CL: 55-65). Evidence at baseline of severe suppression in CD4+ T-lymphocyte count adjusted for age, age at HAART initiation, gender, and having parents alive were statistically significant in predicting time to CD4+ T-lymphocyte recovery. Conclusions. A targeted approach based on predictors of CD4+ T-lymphocyte recovery can be a viable and cost-effective way of monitoring HAART in HIV-infected children in resource-limited settings. © 2011 Lorna Renner et al.
Authors & Co-Authors
A Renner, Lorna
Ghana, Accra
University of Ghana
Prin, Meghan
United States, Piscataway
University of Medicine
Li, Fangyong
United States, New Haven
Yale School of Medicine
Goka, Bamenla Quarm
Ghana, Accra
University of Ghana
Northrup, Veronika Shabanova
United States, New Haven
Yale School of Medicine
Paintsil, Elijah
United States, New Haven
Yale School of Medicine
Statistics
Citations: 15
Authors: 6
Affiliations: 3
Identifiers
Doi:
10.1155/2011/896040
e-ISSN:
20901259
Research Areas
Environmental
Health System And Policy
Infectious Diseases
Maternal And Child Health
Study Locations
Ghana