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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Synthesis and anticonvulsant evaluation of some new 2,3,8-trisubstituted- 4(3H)-quinazoline derivatives
Bioorganic and Medicinal Chemistry Letters, Volume 22, No. 1, Year 2012
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Description
A new series of 2,3,8-trisubstituted-4(3H)-quinazoline derivatives were synthesized, evaluated for their anticonvulsant activity against electrically (MES) and chemically (PTZ, picrotoxin and Strychnine) induced seizures and compared with the standard drugs methaqualone and sodium valproate. Compounds 3, 17 and 22 proved to be the most potent compounds of this series with relatively low neurotoxicity and low toxicity in the median lethal dose test as compared with the reference drugs. The obtained results showed that the most active compounds could be useful as a template for future design, modification and investigation to produce more active analogs. © 2011 Elsevier Ltd. All rights reserved.
Authors & Co-Authors
El-Azab, Adel S.
Saudi Arabia, Riyadh
College of Pharmacy
Egypt, Cairo
Faculty of Pharmacy
ELTahir, Kamal Eldin Hussein
Saudi Arabia, Riyadh
College of Pharmacy
Statistics
Citations: 82
Authors: 2
Affiliations: 2
Identifiers
Doi:
10.1016/j.bmcl.2011.11.007
ISSN:
0960894X
e-ISSN:
14643405