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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Pure dysgerminoma of the ovary: A single institutional experience of 65 patients
Medical Oncology, Volume 29, No. 4, Year 2012
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Description
Ovarian dysgerminomas are rare entity and account for only about 2% of all malignant ovarian neoplasm. The aim of this study was to evaluate the clinicopathologic characteristics, treatment, long-term survival, and fertility outcome of women diagnosed with ovarian dysgerminoma at our institution. Sixty-five women with histologically proven pure ovarian dysgerminoma were identified in this retrospective study. They were treated at King Faisal Specialist Hospital, Riyadh; Saudi Arabia between 1976 and 2010. The median age was 20 years. The most frequent symptoms at presentation were abdominal pain and abdominal/pelvic mass. Thirty-three patients (50.7%) presented with stage I, 2 (3.1%) had stage II, 22 (33.8%) had stage III, and 4 (6.2%) had stage IV (4 unknown stage). Unilateral oophorectomy was performed in 50 patients (76.9%) while bilateral oophorectomy ± hysterectomy was done in 12 patients (18.4%). Three patients had biopsy only. Forty patients (61.5%) received only chemotherapy, and 4 patients (6.2%) received radiotherapy alone. Recurrence was observed in 6 patients (9.2%). With median follow-up of 54 months, the 5-year disease-free survival (DFS) and overall survival (OS) were 88 and 95%, respectively. On univariate analysis, adjuvant chemotherapy was independent better prognostic factor for DFS (HR, 0.09; 95% CI, 0.01-0.84; P = 0.034). Of the 50 patients treated with fertility-sparing surgery, 16 patients (32%) achieved pregnancy with 14 live births. Patients with pure ovarian dysgerminoma have excellent long-term outcome. There is no difference at outcome between fertility-sparing and nonconservative surgeries. Adjuvant chemotherapy was associated with significant improvement in DFS. It is possible to maintain good reproductive function after conservative surgery followed by chemotherapy in our series. © 2012 Springer Science+Business Media, LLC.
Authors & Co-Authors
Al-Husaini, Hamed Homoud
Saudi Arabia, Riyadh
King Faisal Specialist Hospital and Research Centre
Soudy, Hussein
Saudi Arabia, Riyadh
King Faisal Specialist Hospital and Research Centre
Darwish, Alaa El Din
Saudi Arabia, Riyadh
King Faisal Specialist Hospital and Research Centre
Ahmed, Mohamed K.
Saudi Arabia, Riyadh
King Faisal Specialist Hospital and Research Centre
Eltigani, Amin
Saudi Arabia, Riyadh
King Faisal Specialist Hospital and Research Centre
al-Mubarak, Mustafa
Saudi Arabia, Riyadh
King Faisal Specialist Hospital and Research Centre
Sabaa, Amal Abu
Saudi Arabia, Riyadh
King Faisal Specialist Hospital and Research Centre
Edesa, Wael Abdelgawwad
Saudi Arabia, Riyadh
King Faisal Specialist Hospital and Research Centre
Al-Tweigeri, Taher A.
Saudi Arabia, Riyadh
King Faisal Specialist Hospital and Research Centre
Al-Badawi, Ismail A.
Saudi Arabia, Riyadh
King Faisal Specialist Hospital and Research Centre
Statistics
Citations: 51
Authors: 10
Affiliations: 1
Identifiers
Doi:
10.1007/s12032-012-0194-z
e-ISSN:
1559131X
Research Areas
Cancer
Health System And Policy
Maternal And Child Health
Sexual And Reproductive Health
Study Design
Cohort Study
Participants Gender
Female