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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Body mass index, waist circumference and waist-hip ratio: Which is the better discriminator of cardiovascular disease mortality risk? Evidence from an individual-participant meta-analysis of 82864 participants from nine cohort studies
Obesity Reviews, Volume 12, No. 9, Year 2011
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Description
Few studies have examined both the relative magnitude of association and the discriminative capability of multiple indicators of obesity with cardiovascular disease (CVD) mortality risk. We conducted an individual-participant meta-analysis of nine cohort studies of men and women drawn from the British general population resulting in sample of 82864 individuals. Body mass index (BMI), waist circumference (WC) and waist-to-hip ratio (WHR) were measured directly. There were 6641 deaths (1998 CVD) during a mean of 8.1 years of follow-up. After adjustment, a one SD higher in WHR and WC was related to a higher risk of CVD mortality (hazard ratio [95% CI]): 1.15 (1.05-1.25) and 1.15 (1.04-1.27), respectively. The risk of CVD mortality also increased linearly across quintiles of both these abdominal obesity markers with a 66% increased risk in the highest quintile of WHR. In age- and sex-adjusted models only, BMI was related to CVD mortality but not in any other analyses. No major differences were revealed in the discrimination capabilities of models with BMI, WC or WHR for cardiovascular or total mortality outcomes. In conclusion, measures of abdominal adiposity, but not BMI, were related to an increased risk of CVD mortality. No difference was observed in discrimination capacities between adiposity markers. © 2011 The Authors. obesity reviews © 2011 International Association for the Study of Obesity.
Authors & Co-Authors
Czernichow, Seb́astien
France, Villejuif
Centre de Recherche en Épidémiologie et Santé Des Populations
France, Bobigny
Hopital Avicenne
Kengne, Andre-Pascal Pascal
Australia, Sydney
George Institute for International Health
Stamatakis, Emmanuel
United Kingdom, London
University College London
Hamer, Mark
United Kingdom, London
University College London
Batty, George David
United Kingdom, London
University College London
United Kingdom, London
Medical Research Council
Statistics
Citations: 300
Authors: 5
Affiliations: 5
Identifiers
Doi:
10.1111/j.1467-789X.2011.00879.x
ISSN:
1467789X
Research Areas
Environmental
Noncommunicable Diseases
Study Design
Cross Sectional Study
Cohort Study
Study Approach
Systematic review
Participants Gender
Male
Female