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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Contrasting molecular pathology of colorectal carcinoma in Egyptian and Western patients
British Journal of Cancer, Volume 85, No. 7, Year 2001
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Description
Colorectal carcinoma is uncommon in Egypt, but a high proportion of cases occurs before age 40 years and in the rectum. We compared the molecular pathology of 59 representative Egyptian patients aged 10-72 to Western patients with sporadic, young-onset, or hereditary non-polyposis colorectal cancer syndrome (HNPCC)-associated carcinoma and found significant differences. Most Egyptian cancers were rectal (51%) and poorly differentiated (58%). High levels of microsatellite instability (MSI-H) were frequent (37%) and attributable in some cases (36%) to methylation of the promoter of the hMLH1 mismatch repair gene, but no MSI-H cancer had loss of hMSH2 mismatch repair gene product of the type seen with germline hMSH2 mutation in HNPCC. K-ras mutation was uncommon (11%). In subset analyses, high frequencies of MSI-H in rectal carcinomas (36%) and p53 gene product overexpression in MSI-H cancers (50%) were found. MSI-H and K-ras mutation in Egyptians under age 40 were unusual (17% and 0%, respectively), and schistosomiasis was associated with MSI and K-ras mutation. Cluster analysis identified 2 groups: predominantly young men with poorly differentiated mucinous and signet-ring cell colorectal carcinoma lacking K-ras mutation; older patients who had well- or moderately differentiated adenocarcinoma often with MSI-H, K-ras mutation and schistosomiasis. Our findings show that the molecular pathology of colorectal cancer in older as well as younger Egyptians has unique differences from Western patients, and schistosomiasis influences the molecular pathogenesis of some tumours. © 2001 Cancer Research Campaign.
Authors & Co-Authors
Soliman, Amr S.
United States, Houston
The University of Texas Md Anderson Cancer Center
Egypt, Giza
Cairo University
Bondy, Melissa L.
United States, Houston
The University of Texas Md Anderson Cancer Center
El-Badawy, Samy A.
Egypt, Giza
Cairo University
Mokhtar, Nadia Mahmoud
Egypt, Giza
Cairo University
Eissa, Saad Sayed
Egypt, Giza
Cairo University
Bayoumy, S.
Egypt, Tanta
Faculty of Medicine
Seifeldin, Ibrahim A.
Egypt, Tanta
Faculty of Medicine
Houlihan, Patrick Scott
United States, Baltimore
Johns Hopkins School of Medicine
United States, Houston
The University of Texas Md Anderson Cancer Center
Lukish, Jeffrey R.
United States, Bethesda
Walter Reed National Military Medical Center
Watanabe, Toshiaki
United States, Baltimore
Johns Hopkins School of Medicine
Chan, Annie On On
United States, Houston
The University of Texas Md Anderson Cancer Center
Zhu, Dakai
United States, Houston
The University of Texas Md Anderson Cancer Center
Amos, Christopher I.
United States, Houston
The University of Texas Md Anderson Cancer Center
Levin, Bernard
United States, Houston
The University of Texas Md Anderson Cancer Center
Hamilton, Stanley R.
United States, Baltimore
Johns Hopkins School of Medicine
United States, Houston
The University of Texas Md Anderson Cancer Center
Statistics
Citations: 38
Authors: 15
Affiliations: 5
Identifiers
Doi:
10.1038/sj.bjc.6691838
Research Areas
Cancer
Genetics And Genomics
Infectious Diseases
Study Locations
Egypt
Participants Gender
Male