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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Protein tyrosine phosphatase-1B inhibitory activity of isoprenylated flavonoids isolated from Erythrina mildbraedii
Journal of Natural Products, Volume 69, No. 11, Year 2006
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Description
Inhibition of protein tyrosine phosphatase-1B (PTP1B) has been proposed as a therapy for treatment of type-2 diabetes and obesity. Bioassay-guided fractionation of an EtOAc-soluble extract of the root bark of Erythrina mildbraedii, using an in vitro PTP1B inhibitory assay, resulted in the isolation of three new isoprenylated flavonoids, abyssinone-IV-4′-O-methyl ether (2), 7-hydroxy-4′-methoxy-3′-(3-hydroxy-3-methyl-trans-but-1-enyl)- 5′-(3-methylbut-2-enyl)flavanone (3), and abyssinone-VI-4-O-methyl ether (6), along with six known flavonoids, abyssinone-V-4′-O-methyl ether (1), abyssinone-V (4), abyssinone-IV (5), sigmoidin E (7), 4′-hydroxy-5,7- dimethoxyisoflavone (8), and alpinumisoflavone (9). Compounds 1 and 2, 4-7, and 9 inhibited PTP1B activity, with IC50 values ranging from 14.8 ± 1.1 to 39.7 ± 2.5 μM. On the basis of the data obtained, flavanones and chalcones with isoprenyl groups may be considered as a new class of PTP1B inhibitors. © 2006 American Chemical Society and American Society of Pharmacognosy.
Authors & Co-Authors
Na, Minkyun
South Korea, Daejeon
Korea Research Institute of Bioscience and Biotechnology
Jang, Jun Pil
South Korea, Daejeon
Korea Research Institute of Bioscience and Biotechnology
Njamen, Dieudonné
Cameroon, Yaounde
Université de Yaoundé I
Mbafor, Joseph Tanyi
Cameroon, Yaounde
Université de Yaoundé I
Fomum, Zacharias Tanee
Cameroon, Yaounde
Université de Yaoundé I
Kim, Boyeon
South Korea, Daejeon
Korea Research Institute of Bioscience and Biotechnology
Oh, Won Keun
South Korea, Daejeon
Korea Research Institute of Bioscience and Biotechnology
Ahn, Jong Seog
South Korea, Daejeon
Korea Research Institute of Bioscience and Biotechnology
Statistics
Citations: 72
Authors: 8
Affiliations: 2
Identifiers
Doi:
10.1021/np0601861
ISSN:
01633864
Research Areas
Noncommunicable Diseases