Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Laboratory surveillance of synergy between and resistance to trimethoprim and sulfonamides
Reviews of Infectious Diseases, Volume 4, No. 2, Year 1982
Notification
URL copied to clipboard!
Description
Results of susceptibility tests of Enterobacteriaceae isolated at 14 different centers demonstrate synergy between trimethoprim (TMP) and sulfamethoxazole (SMZ) against sulfonamide-susceptible isolates, which account for between < 50% and >75% of the isolates at different centers. Only 1%–4% of the isolates of Escherichia coli or Proteus mirabilis from the five centers in the United States were found to be resistant when tested with a disk containing both TMP and SMZ, but >8% of such isolates from five of the other centers were resistant to the combination disk. A larger percentage of isolates of Klebsiella pneumoniae or Serratia marcescens were resistant, but the number varied from center to center. In the United States, resistance of human and animal isolates of Salmonella to the TMP-SMZ combination was almost completely absent, although >50% of the animal isolates were resistant to sulfonamides. At a center that tested TMP and SMZ resistance with separate disks, resistance to TMP was found to be 30 times more common in sulfonamide-resistant than in sulfonamide-susceptible E. coli. This ratio may be useful as a monitor as treatment with TMP alone increases. © 1982 by The University of Chicago.
Authors & Co-Authors
O’Brien, Thomas F.
United States, Boston
Brigham and Women's Hospital
Acar, Jacqu̧es F.
France, Marseille
Hôpital Saint Joseph
Altmann, G.
Israel, Tel Hashomer Tel Aviv
Chaim Sheba Medical Center Israel
Blackburn, Billie O.
United States, Washington, D.c.
United States Department of Agriculture
Chao, Lee
United States, Boston
Brigham and Women's Hospital
Courtieu, Andre Louis
United States, Paris
Nantes and the Hopital Saint Joseph
Evans, Denis A.
United States, Boston
Channing Division of Network Medicine
Guzmán, Manuel
United States
Med. Cent. Hosp.
Holmes, Marion
United States, Boston
Massachusetts State Laboratory
Jacobs, Michael R.
South Africa, Johannesburg
Chris Hani Baragwanath Hospital
United States, Cleveland
Case Western Reserve University
Kent, Ralph L.
United States, Boston
Brigham and Women's Hospital
Norton, Richard A.
United States, Silver Spring
Food and Drug Administration
Koornhof, Hendrik J.
United States
Johannesburg Hospital
Medeiros, Antone A.
United States, Providence
Brown University
Pasculle, A. William
United States, Pittsburgh
Upmc Presbyterian
Surgalla, Michael J.
United States, Buffalo
Roswell Park Cancer Institute
Williams, J. D.
United Kingdom, London
The Royal London Hospital
Statistics
Citations: 18
Authors: 17
Affiliations: 16
Identifiers
Doi:
10.1093/clinids/4.2.351
ISSN:
01620886
Research Areas
Infectious Diseases