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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Severe Childhood Malaria Syndromes Defined by Plasma Proteome Profiles
PLoS ONE, Volume 7, No. 12, Article e49778, Year 2012
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Description
Background: Cerebral malaria (CM) and severe malarial anemia (SMA) are the most serious life-threatening clinical syndromes of Plasmodium falciparum infection in childhood. Therefore it is important to understand the pathology underlying the development of CM and SMA, as opposed to uncomplicated malaria (UM). Different host responses to infection are likely to be reflected in plasma proteome-patterns that associate with clinical status and therefore provide indicators of the pathogenesis of these syndromes. Methods and Findings: Plasma and comprehensive clinical data for discovery and validation cohorts were obtained as part of a prospective case-control study of severe childhood malaria at the main tertiary hospital of the city of Ibadan, an urban and densely populated holoendemic malaria area in Nigeria. A total of 946 children participated in this study. Plasma was subjected to high-throughput proteomic profiling. Statistical pattern-recognition methods were used to find proteome-patterns that defined disease groups. Plasma proteome-patterns accurately distinguished children with CM and with SMA from those with UM, and from healthy or severely ill malaria-negative children. Conclusions: We report that an accurate definition of the major childhood malaria syndromes can be achieved using plasma proteome-patterns. Our proteomic data can be exploited to understand the pathogenesis of the different childhood severe malaria syndromes. © 2012 Burté et al.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC3514223/bin/pone.0049778.s001.xls
https://efashare.b-cdn.net/share/pmc/articles/PMC3514223/bin/pone.0049778.s002.xls
Authors & Co-Authors
Burté, Florence
United Kingdom, London
Mrc National Institute for Medical Research
Brown, Biobele Jotham
Nigeria, Ibadan
University College Hospital, Ibadan
Orimadegun, Adebola Emmanuel
Nigeria, Ibadan
University College Hospital, Ibadan
Ajetunmobi, Wasiu A.
Nigeria, Ibadan
University College Hospital, Ibadan
Battaglia, Francesca
United Kingdom, London
Mrc National Institute for Medical Research
Ely, Barry K.
United Kingdom, London
Mrc National Institute for Medical Research
Afolabi, Nathaniel K.
Nigeria, Ibadan
University College Hospital, Ibadan
Athanasakis, Dimitrios T.
United Kingdom, London
Mrc National Institute for Medical Research
Akinkunmi, Francis Bola
Nigeria, Ibadan
University College Hospital, Ibadan
Kowobari, Olayinka
Nigeria, Ibadan
University College Hospital, Ibadan
Omokhodion, Samuel Ilenre
Nigeria, Ibadan
University College Hospital, Ibadan
Osinusi, Kikelomo I.
Nigeria, Ibadan
University College Hospital, Ibadan
Akinbami, Felix Olukayode
Nigeria, Ibadan
University College Hospital, Ibadan
Shokunbi, Wuraola Adebola
Nigeria, Ibadan
University College Hospital, Ibadan
Sodeinde, Olugbemiro O.
United Kingdom, London
Mrc National Institute for Medical Research
Nigeria, Ibadan
University College Hospital, Ibadan
Fernandez-Reyes, Delmiro
United Kingdom, London
Mrc National Institute for Medical Research
Nigeria, Ibadan
University College Hospital, Ibadan
Statistics
Citations: 19
Authors: 16
Affiliations: 2
Identifiers
Doi:
10.1371/journal.pone.0049778
e-ISSN:
19326203
Research Areas
Health System And Policy
Infectious Diseases
Maternal And Child Health
Study Design
Cohort Study
Case-Control Study
Study Locations
Nigeria