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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
High prevalence of hepatitis C virus infection and predominance of genotype 4 in rural Gabon
Journal of Medical Virology, Volume 80, No. 9, Year 2008
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Description
Hepatitis C (HCV) molecular epidemiology is documented poorly in central African countries. In response to this, a population-based study of 319 consenting adults resident in a remote village of Gabon was undertaken (mean age: 38 years; age range: 13-85+; sex ratio: 0.74). Screening for anti-HCV antibodies was performed using ELISA and recombinant immunoblot assay. Seropositive samples were assessed further with viral load and genotyping techniques. Sixty-six (20.7%) individuals were HCV seropositive. Viral loads ranged from 600 to 24.9 million IU/ml (median: 372,500). Seroprevalence and viral loads increased significantly with age (P < 10-5 and P < 0.003, respectively). HCV sequences of the 5′UTR genome region were obtained from 60 (90.9%) samples and NS5B region sequences were obtained from 22 (36.6%) samples. All strains belonged to subtypes of genotype 4: 4e (72.7%), 4c (13.6%), 4p (4.5%), 4r (4.5%) and one unclassified genotype 4 strain. Evolutionary analysis of the subtype 4e sequences indicates a period of raised transmission during the early twentieth century. © 2008 Wiley-Liss, Inc.
Authors & Co-Authors
Ndong-Atome, Guy Roger
Gabon
Centre International de Recherches Médicales
Senegal, Dakar
Université Cheikh Anta Diop de Dakar
Makuwa, Maria
Gabon
Centre International de Recherches Médicales
Ouwe-Missi-Oukem-Boyer, Odile N.
Gabon
Centre International de Recherches Médicales
Cameroon, Yaounde
Chantal Biya International Reference Centre for Research on Hiv/aids Prevention and Management
Pybus, Oliver George
United Kingdom, Oxford
University of Oxford
Branger, Michel
France, Paris
Hôpital Bichat-claude-bernard Ap-hp
Le Hello, Simon
Gabon
Centre International de Recherches Médicales
New Caledonia, Noumea
Institut Pasteur de Nouvelle-caledonie Noumea
Boye-Cheik, S. B.
Senegal, Dakar
Université Cheikh Anta Diop de Dakar
Brun-Vézinet, Françoise
France, Paris
Hôpital Bichat-claude-bernard Ap-hp
Kazanji, Mirdad
Gabon
Centre International de Recherches Médicales
Roques, Pierre A.
Gabon
Centre International de Recherches Médicales
France, Fontenay-aux-roses
Cea Fontenay Aux Roses
Bisser, Sylvie
Gabon
Centre International de Recherches Médicales
France, Limoges
Institut D’epidémiologie Neurologique et de Neurologie Tropicale
Statistics
Citations: 32
Authors: 11
Affiliations: 8
Identifiers
Doi:
10.1002/jmv.21252
ISSN:
01466615
e-ISSN:
10969071
Research Areas
Genetics And Genomics
Infectious Diseases
Study Design
Cross Sectional Study
Study Locations
Gabon