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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Severe falciparum malaria in young children of the Kassena-Nankana district of northern Ghana
Malaria Journal, Volume 6, Article 96, Year 2007
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Description
Study design. Severe falciparum malaria in children was studied as part of the characterization of the Kassena-Nankana District Ghana for future malaria vaccine trials. Children aged 6-59 months with diagnosis suggestive of acute disease were characterized using the standard WHO definition for severe malaria. Results. Of the total children screened, 45.2% (868/1921) satisfied the criteria for severe malaria. Estimated incidence of severe malaria was 3.4% (range: 0.4-8.3%) cases per year. The disease incidence was seasonal: 560 cases per year, of which 70.4% occurred during the wet season (June-October). The main manifestations were severe anaemia (36.5%); prolonged or multiple convulsions (21.6%); respiratory distress (24.4%) and cerebral malaria (5.4%). Others were hyperpyrexia (11.1%); hyperparasitaemia (18.5%); hyperlactaemia (33.4%); and hypoglycaemia (3.2%). The frequency of severe anaemia was 39.8% in children of six to 24 months of age and 25.9% in children of 25-60 months of age. More children (8.7%) in the 25-60 months age group had cerebral malaria compared with 4.4% in the 6-24 months age group. The overall case fatality ratio was 3.5%. Cerebral malaria and hyperlactataemia were the significant risk factors associated with death. Severe anaemia, though a major presentation, was not significantly associated with risk of death. Conclusion. Severe malaria is a frequent and seasonal childhood disease in northern Ghana and maybe an adequate endpoint for future malaria vaccine trials. © 2007 Oduro et al; licensee BioMed Central Ltd.
Authors & Co-Authors
Oduro, Abraham Rexford
Ghana, Navrongo
Navrongo Health Research Center
Koram, Kwadwo A.
Ghana, Accra
Noguchi Memorial Institute for Medical Research
Rogers, William Oscar
United States, Silver Spring
Naval Medical Research Center
Atuguba, Frank
Ghana, Navrongo
Navrongo Health Research Center
Ansah, Patrick Odum
Ghana, Navrongo
Navrongo Health Research Center
Anyorigiya, Thomas A.
Ghana, Navrongo
Navrongo Health Research Center
Ansah, Akosua
Ghana, Navrongo
Navrongo Health Research Center
Anto, Francis R.
Ghana, Navrongo
Navrongo Health Research Center
Mensah, Nathan Kumasenu
Ghana, Navrongo
Navrongo Health Research Center
Hodgson, Abraham V.O.
Ghana, Navrongo
Navrongo Health Research Center
Nkrumah, Francis K.
Ghana, Accra
Noguchi Memorial Institute for Medical Research
Statistics
Citations: 89
Authors: 11
Affiliations: 3
Identifiers
Doi:
10.1186/1475-2875-6-96
e-ISSN:
14752875
Research Areas
Infectious Diseases
Maternal And Child Health
Study Design
Cohort Study
Study Locations
Ghana