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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Time trends in demographic and clinical characteristics of adult patients on HAART initiation in West Africa
Medecine et Maladies Infectieuses, Volume 40, No. 8, Year 2010
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Description
We studied the evolution of drug combinations used, as well as the clinical and immunological profile of patients at initiation of highly active antiretroviral therapy (HAART) between 1996 and 2006 in West Africa. Settings and method: IeDEA West Africa is a network of HIV care programs established in 2006. We analyzed data from 12 clinical centers treating adults in five countries: Benin, Cote d'Ivoire, Senegal, Gambia, and Mali. Patients 16 years of age or over were included in the study and the following was documented: sex, date of birth and date of initiation of HAART. Results: We included 14,496 adult patients having started HAART, among these 55 % had started HAART between 2005-2006. The proportion of HIV-infected women increased from 46 % in 1996-2000 to 63 % in 2005-2006. The median age at HAART initiation remained constant: 35 years for women and 40 years for men. The proportion of patients having started HAART with a CD4 count < 200 cells/μl was 54 % in 1996-2000, and 64 % in 2005-2006. The most frequently prescribed HAART was: AZT/3TC (or d4T/DDI)/IDV (27 %) in 1996-2000; d4T (or AZT)/3TC/EFV (49 %) in 2003-2004, and d4T/3TC/NVP (49 %) in 2005-2006. Conclusion: The first line HAART regimen recommended by WHO was initiated in 83 % of cases in 2005-2006. New approaches to an earlier initiation of ART should be explored to reduce mortality in HIV-infected patients on HAART. © 2009 Elsevier Masson SAS.
Authors & Co-Authors
Bashi, Jules B.
Benin
Chnu
Balestre, Eric
France, Paris
Inserm
Messou, Eugéne
Cote D'ivoire, Abidjan
Cepref-enfants
Maïga, Moussa Youssouffa
Mali, Bamako
Hopital Gabriel Toure
Coffié, Patrick Ahuatchi
France, Paris
Inserm
Cote D'ivoire, Abidjan
Operations Research Iedea
Zannou, Djimon Marcel
Benin
Chnu
Ba-Gomis, Olivier
Cote D'ivoire, Abidjan
Centre Intégré de Recherches Biocliniques D'abidjan Cirba
Traoré, Hammar Alassane
Mali, Bamako
Hopital National du Point g
Eholié, Serge Paul
Cote D'ivoire, Abidjan
Centre Hospitalier Universitaire de Treichville
Minga, Albert Kla
Cote D'ivoire, Abidjan
Centre Médical de Suivi de Donneurs de Sang/cnts/primo-ci
Sow, Papa Salif
Senegal, Dakar
Centre Hospitalier Universitaire Dakar
Bissagnéné, Emmanuel
Cote D'ivoire, Abidjan
Centre Hospitalier Universitaire de Treichville
Dabis, Franćois Ç.Ois
France, Paris
Inserm
Ékouévi, Didier Koumavi
France, Paris
Inserm
Cote D'ivoire, Abidjan
Operations Research Iedea
Statistics
Citations: 14
Authors: 14
Affiliations: 10
Identifiers
Doi:
10.1016/j.medmal.2009.11.003
ISSN:
0399077X
Research Areas
Infectious Diseases
Study Locations
Multi-countries
Benin
Gambia
Ivory Coast
Mali
Senegal
Participants Gender
Male
Female