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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
Comparative study on the efficacy of Allium sativum (garlic) in reducing some heavy metal accumulation in liver of wistar rats
Food and Chemical Toxicology, Volume 50, No. 2, Year 2012
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Description
Scope: Heavy metals are known to cause damage through indirect oxidative effects. This study was undertaken to compare the therapeutic efficacy and protective ability of garlic extracts on reducing toxicity induced by mercury, lead and cadmium in the liver. Methods and results: Rats were fed with rat chow mixed with raw garlic (7% w/w) while mercury (10. ppm), cadmium (200. ppm) and lead (100. ppm) were given in drinking water. Garlic was administered either at the same time with the metals (group 2), a week after exposure to heavy metals (group 3) or a week before heavy metal exposure (group 4) for 6. weeks. The heavy metal accumulations in the liver were determined using AAS. The percentage protection showed a time-dependent effect and was significantly (P< 0.01) higher for cadmium compared to mercury and lead-treated groups. Analysis between the groups showed that garlic treatment after exposure had a significantly (P< 0.05) higher percentage protection when compared with other modes. Conclusion: These results suggest that garlic offered more hepatoprotective effect to cadmium followed by mercury and least protection to lead at the selected dose of each metal in this study through the processes of uptake, assimilation and elimination of these metals. © 2011 Elsevier Ltd.
Authors & Co-Authors
Nwokocha, Chukwuemeka Raphael
Jamaica, Kingston
The University of the West Indies
Owu, Daniel Udofia
Jamaica, Kingston
The University of the West Indies
Nwokocha, Magdalene I.
Jamaica, Kingston
The University of the West Indies
Ufearo, Chibueze S.
Nigeria, Awka
Nnamdi Azikiwe University
Iwuala, Moses O.E.
Nigeria, Owerri
Federal University of Technology, Owerri
Statistics
Citations: 53
Authors: 5
Affiliations: 3
Identifiers
Doi:
10.1016/j.fct.2011.11.003
ISSN:
02786915
e-ISSN:
18736351
Research Areas
Environmental