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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
First line therapy with paclitaxel (Taxol®) and pegylated liposomal doxorubicin (Caelyx®) in patients with metastatic breast cancer: A multicentre phase II study
Breast, Volume 13, No. 3, Year 2004
Notification
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Description
The aim of this multicentric phase II study was to investigate the efficacy and toxicity of a combination of chemotherapy containing paclitaxel (Taxol®) and a novel compound, a liposomal encapsulated doxorubicin (Caelyx®), as first line therapy for patients with metastatic breast cancer. Thirty-four patients with advanced breast cancer were treated with a combination of paclitaxel 175 mg/m2 and liposomal doxorubicin 30 mg/m2, every 3 weeks. The combination chemotherapy was effective in 73% of the patients (ITT) (95% CI 55-86%) (7 complete and 18 partial responses). Grade 3/4 toxicities were documented in a small number of patients. Two toxic eaths (6%) were documented, one a hepatorenal failure and another a febrile neutropenia. One patient experienced pulmonary embolism but continued on treatment after appropriate therapy. The combination of paclitaxel and liposomal encapsulated doxorubicin induces a high and durable response rate with a moderate toxicity profile. © 2004 Elsevier Ltd. All rights reserved.
Authors & Co-Authors
Vorobiof, Daniel Alberto
South Africa, Johannesburg
Sandton Oncology Centre
Rapoport, Bernardo L.
South Africa, Johannesburg
Medical Oncology Centre of Rosebank
Chasen, Martin Robert
South Africa, Pretoria
Mary Potter Oncology Centre
Slabber, Coenraad Frederik
South Africa, Pretoria
Mary Potter Oncology Centre
South Africa, Pretoria
University of Pretoria
McMichael, G.
South Africa, Johannesburg
West Rand Oncology Centre
Eek, Richard W.
South Africa, Pretoria
Mary Potter Oncology Centre
Mohammed, C.
South Africa, Johannesburg
Sandton Oncology Centre
Statistics
Citations: 45
Authors: 7
Affiliations: 5
Identifiers
Doi:
10.1016/j.breast.2004.01.006
ISSN:
09609776
Research Areas
Cancer
Environmental
Health System And Policy