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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Immunohistologic localization of alpha, Mu, and Pi class glutathione S‐transferases in human tissues
Cancer, Volume 67, No. 6, Year 1991
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Description
Human alpha, pi, and mu class glutathione S‐transferases (GSH S‐T) have been localized immunohistologically in a variety of organs. Alpha GSH S‐T are found principally in hepatocytes, proximal convoluted tubules of kidney, the deep reticular layer of the adrenal gland, interstitial cells of the testis, and oxyntic cells of the stomach. The pi GSH S‐T are present in relative abundance in ductular, as opposed to parenchymal cells in the liver, pancreas, salivary glands, and kidney. The presence of mu GSH S‐T in the tissues of certain patients and its absence in the same tissues from other patients has been demonstrated. The pi GSH S‐T seems to be most persistently and strongly expressed in tumors but alpha GSH S‐T are also found in some neoplasms whereas the mu GSH S‐T are occasionally present when the other two transferases are weak or absent. Copyright © 1991 American Cancer Society
Authors & Co-Authors
Campbell, John A.H.
South Africa, Cape Town
University of Cape Town
Corrigall, Anne V.
South Africa, Cape Town
University of Cape Town
Guy, A.
South Africa, Cape Town
University of Cape Town
Kirsch, Ralph Emmanuel
South Africa, Cape Town
University of Cape Town
Statistics
Citations: 140
Authors: 4
Affiliations: 1
Identifiers
Doi:
10.1002/1097-0142(19910315)67:6<1608::AID-CNCR2820670623>3.0.CO;2-S
ISSN:
0008543X
e-ISSN:
10970142
Research Areas
Cancer