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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
Curcuminoids, curcumin, and demethoxycurcumin reduce lead-induced memory deficits in male wistar rats
Journal of Agricultural and Food Chemistry, Volume 55, No. 3, Year 2007
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Description
This study investigated the neuroprotective effects of the curcuminoids against lead-induced neurotoxicity. The results show that lead significantly increases lipid peroxidation and reduces the viability of primary hippocampal neurons in culture. This lead-induced toxicity was significantly curtailed by the co-incubation of the neurons with the curcuminoids. In a whole animal experiment, rats were trained in a water maze and thereafter dosed with lead and/or curcumin (CURC), demethoxycurcumin (DMC), or bisdemethoxycurcumin (BDMC) for 5 days. Animals treated with curcumin and demethoxycurcumin but not bisdemethoxycurcumin had more glutathione and less oxidized proteins in the hippocampus than those treated with lead alone. These animals also had faster escape latencies when compared to the Pb-treated animals indicating that CURC- and DMC-treated animals retain the spatial reference memory. The findings of this study indicate that curcumin, a well-established dietary antioxidant, is capable of playing a major role against heavy metal-induced neurotoxicity and has neuroprotective properties. © 2007 American Chemical Society.
Authors & Co-Authors
Dairam, Amichand
South Africa, Grahamstown
Rhodes University
Limson, Janice Leigh
South Africa, Grahamstown
Rhodes University
Watkins, Gareth Mostyn
South Africa, Grahamstown
Rhodes University
Antunes, Edith M.
South Africa, Grahamstown
Rhodes University
Daya, Santy
South Africa, Grahamstown
Rhodes University
Statistics
Citations: 107
Authors: 5
Affiliations: 1
Identifiers
Doi:
10.1021/jf063446t
ISSN:
00218561
Research Areas
Environmental
Study Approach
Quantitative
Participants Gender
Male