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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Mitochondrial DNA structure in North Africa reveals a genetic discontinuity in the Nile Valley
American Journal of Physical Anthropology, Volume 145, No. 1, Year 2011
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Description
Human population movements in North Africa have been mostly restricted to an east-west direction due to the geographical barriers imposed by the Sahara Desert and the Mediterranean Sea. Although these barriers have not completely impeded human migrations, genetic studies have shown that an east-west genetic gradient exists. However, the lack of genetic information of certain geographical areas and the focus of some studies in parts of the North African landscape have limited the global view of the genetic pool of North African populations. To provide a global view of the North African genetic landscape and population structure, we have analyzed ∼2,300 North African mitochondrial DNA lineages (including 269 new sequences from Libya, in the first mtDNA study of the general Libyan population). Our results show a clinal distribution of certain haplogroups, some of them more frequent in Western (H, HV0, L1b, L3b, U6) or Eastern populations (L0a, R0a, N1b, I, J) that might be the result of human migrations from the Middle East, sub-Saharan Africa, and Europe. Despite this clinal pattern, a genetic discontinuity is found in the Libyan/Egyptian border, suggesting a differential gene flow in the Nile River Valley. Finally, frequency of the post-LGM subclades H1 and H3 is predominant in Libya within the H sequences, highlighting the magnitude of the LGM expansion in North Africa. © 2011 Wiley-Liss, Inc.
Authors & Co-Authors
Fadhlaoui-Zid, Karima
Tunisia, Tunis
Université de Tunis el Manar, Faculté Des Sciences de Tunis
Botigué, Laura R.
Spain, Barcelona
Universitat Pompeu Fabra Barcelona
Naoui, Nejib
Tunisia, Tunis
Laboratory of Medical Imaging
Benammar-Elgaaïed, Amel
Tunisia, Tunis
Université de Tunis el Manar, Faculté Des Sciences de Tunis
Calafell, Francesc
Spain, Barcelona
Universitat Pompeu Fabra Barcelona
Spain, Madrid
Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública
Comas, D.
Spain, Barcelona
Universitat Pompeu Fabra Barcelona
Spain, Madrid
Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública
Statistics
Citations: 43
Authors: 6
Affiliations: 4
Identifiers
Doi:
10.1002/ajpa.21472
ISSN:
00029483
e-ISSN:
10968644
Research Areas
Genetics And Genomics
Study Design
Cross Sectional Study
Study Locations
Multi-countries
Libya