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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
C-reactive protein and familial risk for dementia; A phenotype for successful cognitive aging
Neurology, Volume 79, No. 11, Year 2012
Notification
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Description
Objectives: Identifying phenotypes for successful cognitive aging, intact cognition into late-old age (-age 75), can help identify genes and neurobiological systems that may lead to interventions against and prevention of late-life cognitive impairment. The association of C-reactive protein (CRP) with cognitive impairment and dementia, observed primarily in young-elderly samples, appears diminished or reversed in late-old age (75- years). A family history study determined if high CRP levels in late-old aged cognitively intact probands are associated with a reduced risk of dementia in their first-degree family members, suggesting a familial successful cognitive aging phenotype. Methods: The primary sample was 1,329 parents and siblings of 277 cognitively intact male veteran probands at least 75 years old. The replication sample was 202 relatives of 51 cognitively intact community-ascertained probands at least 85 years old. Relatives were assessed for dementia by proband informant interview. Their hazard ratio (HR) for dementia as a function of the proband's log-transformed CRP was calculated using the proportional hazards model. Results: Covarying for key demographics, higher CRP in probands was strongly associated with lower risk of dementia in relatives (HR = 0.55 [95% confidence interval (CI) 0.41, 0.74], p < 0.02). The replication sample relationship was in the same direction, stronger in magnitude, and also significant (HR = 0.15 [95% CI 0.06, 0.37], p < 0.0001). Conclusions: Relatives of successful cognitive aging individuals with high levels of CRP are relatively likely to remain free of dementia. High CRP in successful cognitive aging individuals may constitute a phenotype for familial-and thus possibly genetic-successful cognitive aging. © 2012 by AAN Enterprises, Inc.
Authors & Co-Authors
Silverman, Jeremy M.
United States, New York
Icahn School of Medicine at Mount Sinai
United States
Va Medical Center
Schmeidler, James M.
United States, New York
Icahn School of Medicine at Mount Sinai
Rosendorff, Clive
United States, New York
Icahn School of Medicine at Mount Sinai
United States
Va Medical Center
Grossman, Hillel T.
United States, New York
Icahn School of Medicine at Mount Sinai
United States
Va Medical Center
Haroutunian, Vahram H.
United States, New York
Icahn School of Medicine at Mount Sinai
United States
Va Medical Center
Statistics
Citations: 24
Authors: 5
Affiliations: 3
Identifiers
Doi:
10.1212/WNL.0b013e3182698c89
ISSN:
00283878
Research Areas
Environmental
Genetics And Genomics
Mental Health
Participants Gender
Male