Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Influence of Variations in CCL3L1 and CCR5 on Tuberculosis in a Northwestern Colombian Population
Journal of Infectious Diseases, Volume 203, No. 11, Year 2011
Notification
URL copied to clipboard!
Description
We investigated the association of polymorphisms in CCR5, the major human immunodeficiency virus (HIV)-1 coreceptor, and copy number of its potent ligand CCL3L1 with tuberculosis in 298 individuals from Colombia. The CCR5-HHD haplotype, a known genetic determinant of increased susceptibility to HIV-AIDS, and a high copy number of CCL3L1, a known genetic determinant of enhanced CCL3/CCL3L1 chemokine expression, each associated with presence of tuberculosis. Furthermore, CCR5-HHD was associated with higher CCR5 gene and surface expression. These results substantiate the strong link between the proinflammatory effects of CCR5 and its ligands with active tuberculosis and suggest that chemokine-chemokine receptor genetic determinants may influence tuberculosis in addition to HIV/AIDS. © The Author 2011. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC3096789/bin/supp_203_11_1590__index.html
https://efashare.b-cdn.net/share/pmc/articles/PMC3096789/bin/supp_jir145_Mamtani_et_al_SOM.doc
Authors & Co-Authors
Mamtani, Manju
United States, San Antonio
South Texas Veterans Health Care System
Mummidi, Srinivas
United States, San Antonio
South Texas Veterans Health Care System
Ramsuran, Veron
South Africa, Congella
Centre for the Aids Programme of Research in South Africa
South Africa, Durban
The Nelson R. Mandela Medical School
Pham, Minh Hieu
United States, San Antonio
South Texas Veterans Health Care System
Maldonado, Robert
United States, San Antonio
South Texas Veterans Health Care System
Begum, Kazi
United States, San Antonio
South Texas Veterans Health Care System
Valera, Maria Soledad
United States, San Antonio
South Texas Veterans Health Care System
Sanchez, Racquel
United States, San Antonio
South Texas Veterans Health Care System
Castiblanco, John
United States, San Antonio
South Texas Veterans Health Care System
Kulkarni, Hemant
United States, San Antonio
South Texas Veterans Health Care System
Ndung'u, Thumbi P.
South Africa, Congella
Centre for the Aids Programme of Research in South Africa
South Africa, Durban
The Nelson R. Mandela Medical School
He, Weijing
United States, San Antonio
South Texas Veterans Health Care System
Anaya, Juan Manuel
Colombia, Medellin
Corporacion Para Investigaciones Biologicas
Colombia, Bogota
Universidad Del Rosario
Ahuja, Sunil K.
United States, San Antonio
South Texas Veterans Health Care System
United States, San Antonio
University of Texas Health Science Center at San Antonio
Statistics
Citations: 14
Authors: 14
Affiliations: 6
Identifiers
Doi:
10.1093/infdis/jir145
ISSN:
00221899
Research Areas
Genetics And Genomics
Infectious Diseases
Study Design
Cross Sectional Study