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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Eye movements in parkinsonian syndromes
Annals of Neurology, Volume 35, No. 4, Year 1994
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Description
Eye movements were recorded in 14 patients with Parkinson's disease (PD) in the “off” condition, 14 patients with striatonigral degeneration (SND), 10 patients with corticobasal degeneration (CBD), and 10 patients with progressive supranuclear palsy (PSP), with comparison with 12 control subjects. Vertical saccade paralysis was not observed in the PD, SND, and CBD groups but was present in 9 patients of 10 in the PSP group. In the PD and SND groups, horizontal reflexive visually guided saccade latency and accuracy were similar, and differed only slightly from those of controls. In the CBD group, saccade latency was significantly increased and correlated to an “apraxia score”; whereas, in the PSP group, saccade amplitude was significantly decreased. Thus, the abnormalities of both horizontal saccade parameters in the PSP group contrasted with those observed in the CBD group. The percentage of errors in the antisaccade task, an index of prefrontal dysfunction, was markedly increased only in the PSP group. The smooth pursuit gain was decreased in all groups but more severely in the PSP group. It may be concluded that saccade abnormalities are clearly different in SND, CBD, and PSP, and might help in early differential diagnosis in individual patients, but that SND cannot be differentiated from PD on the simple basis of eye movement abnormalities. Copyright © 1994 American Neurological Association
Authors & Co-Authors
Vidailhet, Marie J.
France, Paris
Inserm
Gouider-Khouja, Neziha
France, Paris
Inserm
Bonnet, Anne Marie
France, Paris
Inserm
Gaymard, Bertrand M.
France, Paris
Inserm
Agid, Yves A.
France, Paris
Inserm
Statistics
Citations: 256
Authors: 5
Affiliations: 1
Identifiers
Doi:
10.1002/ana.410350408
ISSN:
03645134
Research Areas
Disability
Health System And Policy