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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
E-cigarettes compromise the gut barrier and trigger inflammation
iScience, Volume 24, No. 2, Article 102035, Year 2021
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Description
Biological Sciences; Physiology; Toxicology; Microbiology; Microbiome; Transcriptomics © 2021 The Author(s); E-cigarette usage continues to rise, yet the safety of e-cigarette aerosols is questioned. Using murine models of acute and chronic e-cigarette aerosol inhalation, murine colon transcriptomics, and murine and human gut-derived organoids in co-culture models, we assessed the effects of e-cigarette use on the gut barrier. Histologic and transcriptome analyses revealed that chronic, but not acute, nicotine-free e-cigarette use increased inflammation and reduced expression of tight junction (TJ) markers. Exposure of murine and human enteroid-derived monolayers (EDMs) to nicotine-free e-cigarette aerosols alone or in co-culture with bacteria also causes barrier disruption, downregulation of TJ protein, and enhanced inflammation in response to infection. These data highlight the harmful effects of “non-nicotine” component of e-cigarettes on the gut barrier. Considering the importance of an intact gut barrier for host fitness and the impact of gut mucosal inflammation on a multitude of chronic diseases, these findings are broadly relevant to both medicine and public health. © 2021 The Author(s)
Authors & Co-Authors
Sharma, Aditi
United States, La Jolla
University of California, San Diego
Moshensky, Alexander
United States, La Jolla
University of California, San Diego
Sayed, Ibrahim Mohamoud
United States, La Jolla
University of California, San Diego
Ibeawuchi, Stella Rita
United States, La Jolla
University of California, San Diego
Pranadinata, Rama F.
United States, La Jolla
University of California, San Diego
Ear, Jason
United States, La Jolla
University of California, San Diego
Sahoo, Debashis
United States, La Jolla
University of California, San Diego
United States, La Jolla
Uc San Diego Jacobs School of Engineering
Crotty-Alexander, Laura E.
United States, La Jolla
University of California, San Diego
United States, San Diego
Va San Diego Healthcare System
Ghosh, Pradipta
United States, La Jolla
University of California, San Diego
United States, San Diego
Va San Diego Healthcare System
Das, Soumita
United States, La Jolla
University of California, San Diego
Statistics
Citations: 27
Authors: 10
Affiliations: 3
Identifiers
Doi:
10.1016/j.isci.2021.102035
ISSN:
25890042
Research Areas
Health System And Policy
Substance Abuse