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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Designing and implementing sample and data collection for an international genetics study: The Type 1 Diabetes Genetics Consortium (T1DGC)
Clinical Trials, Volume 7, No. 1_suppl, Year 2010
Notification
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Description
Background and Purpose The Type 1 Diabetes Genetics Consortium (T1DGC) is an international project whose primary aims are to: (a) discover genes that modify type 1 diabetes risk; and (b) expand upon the existing genetic resources for type 1 diabetes research. The initial goal was to collect 2500 affected sibling pair (ASP) families worldwide. Methods T1DGC was organized into four regional networks (Asia-Pacific, Europe, North America, and the United Kingdom) and a Coordinating Center. A Steering Committee, with representatives from each network, the Coordinating Center, and the funding organizations, was responsible for T1DGC operations. The Coordinating Center, with regional network representatives, developed study documents and data systems. Each network established laboratories for: DNA extraction and cell line production; human leukocyte antigen genotyping; and autoantibody measurement. Samples were tracked from the point of collection, processed at network laboratories and stored for deposit at National Institute for Diabetes and Digestive and Kidney Diseases (NIDDK) Central Repositories. Phenotypic data were collected and entered into the study database maintained by the Coordinating Center. Results T1DGC achieved its original ASP recruitment goal. In response to research design changes, the T1DGC infrastructure also recruited trios, cases, and controls. Results of genetic analyses have identified many novel regions that affect susceptibility to type 1 diabetes. T1DGC created a resource of data and samples that is accessible to the research community. Limitations Participation in T1DGC was declined by some countries due to study requirements for the processing of samples at network laboratories and/or final deposition of samples in NIDDK Central Repositories. Re-contact of participants was not included in informed consent templates, preventing collection of additional samples for functional studies. Conclusions T1DGC implemented a distributed, regional network structure to reach ASP recruitment targets. The infrastructure proved robust and flexible enough to accommodate additional recruitment. T1DGC has established significant resources that provide a basis for future discovery in the study of type 1 diabetes genetics. © The Author(s) 2010.
Authors & Co-Authors
Hilner, Joan E.
United States, Birmingham
The University of Alabama at Birmingham
Perdue, Letitia H.
United States, Winston Salem
Wake Forest University Health Sciences
Sides, Elizabeth G.
United States, Winston Salem
Wake Forest University Health Sciences
Pierce, June J.
United States, Winston Salem
Wake Forest University Health Sciences
Wägner, Ana María
Denmark, Gentofte
Hagedorn Research Institute
Spain, Las Palmas de Gran Canaria
Complejo Hospitalario Universitario Insular Materno-infantil
Spain, Las Palmas de Gran Canaria
Universidad de Las Palmas de Gran Canaria
Aldrich, Alan
United States, Anchorage
University of Alaska Anchorage
Loth, Amanda
Australia, Melbourne
Walter and Eliza Hall Institute of Medical Research
Albret, Lotte
Denmark, Gentofte
Hagedorn Research Institute
Wagenknecht, Lynne E.
United States, Winston Salem
Wake Forest University Health Sciences
Nierras, Concepcion R.
United States, New York
Juvenile Diabetes Research Foundation International
Akolkar, Beena
United States, Bethesda
National Institutes of Health Nih
Baskerville, Tracey
Australia, Brisbane
Mater Hospitals
Bautista, Nines
Philippines
Institute for Studies on Diabetes Foundation
Bhatia, Eesh
India, Lucknow
Sanjay Gandhi Postgraduate Institute of Medical Sciences
Bhatia, Vijayalakshmi L.
India, Lucknow
Sanjay Gandhi Postgraduate Institute of Medical Sciences
Bin Hasan, Kamaruzaman
Malaysia, Bangi
Universiti Kebangsaan Malaysia
Bonnici, François B.
South Africa, Cape Town
University of Cape Town
Brodnicki, Thomas C.
Australia, Melbourne
Walter and Eliza Hall Institute of Medical Research
Browning, Brian L.
New Zealand, Auckland
The University of Auckland
Cameron, Fergus J.
Australia, Melbourne
Royal Children's Hospital, Melbourne
Chaichanwatanakul, Katharee
Thailand, Nakhon Pathom
Mahidol University
To Cheung, Pik
Hong Kong
Queen Mary Hospital Hong Kong
Colman, P. G.
Australia, Melbourne
Walter and Eliza Hall Institute of Medical Research
Cotterill, Andrew Michael
Australia, Brisbane
Mater Hospitals
Couper, Jennifer J.
Australia, Adelaide
Women’s and Children’s Hospital
Crock, Patricia A.
Australia
John Hunter Childrens Hospital
Cutfield, Ric
New Zealand, Auckland
North Shore Hospital
Davis, Timothy M.E.
Australia, Fremantle
Fremantle Hospital
Dixon, Paul
New Zealand, Whangarei
Diabetes Lifestyle Centre
Donaghue, Kim C.
Australia, Sydney
The Children's Hospital at Westmead
Dowling, Katrina
Australia, Melbourne
Australian Red Cross Blood Service
Drury, Paul Leslie
New Zealand, Auckland
Auckland Diabetes Centre
Dye, Sarah
Australia, Perth
The Harry Perkins Institute of Medical Research
Gellert, Shane A.
Australia, Melbourne
Royal Melbourne Hospital
Abdul Ghani, Rohana
Malaysia, Bangi
Universiti Kebangsaan Malaysia
Greer, R. M.
Australia, Brisbane
The University of Queensland
Han, Xueyao
China, Beijing
Peking University People's Hospital
Harrison, L. C.
Australia, Melbourne
Walter and Eliza Hall Institute of Medical Research
Homatopoulos, Nick
Australia, Melbourne
Australian Red Cross Blood Service
Ji, Linong
China, Beijing
Peking University People's Hospital
Jones, Timothy W.
Australia, Perth
Princess Margaret Hospital for Children
Kah Yin, Loke
Singapore, Singapore City
Children's Medical Institute
Kamaruddin, Nor Azmi Zmi
Malaysia, Bangi
Universiti Kebangsaan Malaysia
Kanga, Uma
India, New Delhi
Ministry of Health and Family Welfare
Kanungo, Alok
India, Cuttak
Cuttack Diabetes Foundation
Kaur, Gurvinder
India, New Delhi
Ministry of Health and Family Welfare
Kek, Betty Lay Kee
Singapore, Singapore City
Children's Medical Institute
Knowles, Simon
Australia, Melbourne
Australian Red Cross Blood Service
Krebs, Jeremy D.
New Zealand, Canterbury
Diabetes Centre
Lee, Yannjinn
Taiwan, Taipei
Mackay Memorial Hospital Taiwan
Liktimaskul, Supawadee
Thailand, Nakhon Pathom
Mahidol University
Lloyd, Margaret
Australia, Sydney
The Children's Hospital at Westmead
Louey, Anthony
Australia, Melbourne
Australian Red Cross Blood Service
Mehra, Narinder Kumar
India, New Delhi
Ministry of Health and Family Welfare
Merriman, Tony R.
New Zealand, Dunedin
University of Otago
Min, Liu
China, Beijing
Beijing Children's Hospital, Capital Medical University
Morahan, Grant E.
Australia, Perth
The Harry Perkins Institute of Medical Research
Moses, Robert Geoffrey
Australia
Illawarra Diabetes Services
Mraz, Grant A.
Australia, Melbourne
Australian Red Cross Blood Service
Murphy, Rinki P.
New Zealand, Auckland
Auckland Diabetes Centre
Nicholson, Ian C.
Australia, Melbourne
Australian Red Cross Blood Service
Panelo, Araceli A.
Philippines
Institute for Studies on Diabetes Foundation
Poh, Perlita
Australia, Melbourne
Royal Melbourne Hospital
Price, Gareth R.
Australia, Brisbane
Mater Medical Research Institute
Ratnam, Nirubasini
Australia, Perth
Princess Margaret Hospital for Children
Sanjeevi, Carani Balaraman
Sweden, Stockholm
Karolinska Universitetssjukhuset
Sedimbi, Saikiran K.
Sweden, Stockholm
Karolinska Universitetssjukhuset
Shen, Shuixian
China, Shanghai
Fudan University
Siok Ying, Goh
Singapore, Singapore City
Children's Medical Institute
Tait, Brian D.
Australia, Melbourne
Australian Red Cross Blood Service
Tandon, Nikhil
India, New Delhi
Ministry of Health and Family Welfare
Thomas, Allison L.
Australia, Melbourne
Walter and Eliza Hall Institute of Medical Research
Varney, Michael D.
Australia, Melbourne
Australian Red Cross Blood Service
Weerakulwattana, Praewvarin
Thailand, Nakhon Pathom
Mahidol University
Willis, Jinny
New Zealand, Christchurch
Christchurch Hospital new Zealand
Akwo, Elvis Abang
Cameroon, Yaounde
Central Hospital of Yaounde Fmbs
Ampudia-Blasco, Francisco Javier
Denmark, Herlev
Steno Diabetes Center Copenhagen
Argenté, Jésus
Spain, Madrid
Hospital Infantil Universitario Niño Jesús
Avbelj Stefanija, Magdalena
Slovenia, Ljubljana
University Children’s Hospital
Babadjanova, Goulnara
Russian Federation, Moscow
Pirogov Russian National Research Medical University Rnrmu
Badenhoop, Klaus
Germany, Frankfurt am Main
Universitätsklinikum Frankfurt
Battelino, Tadej
Slovenia, Ljubljana
University Children’s Hospital
Beilhack, Georg F.
Germany, Ulm
Universität Ulm
Bergholdt, Regine
Denmark, Gentofte
Hagedorn Research Institute
Bingley, Polly J.
United Kingdom, Bristol
University of Bristol
Böehm, Bernhard Otto
Germany, Ulm
Universität Ulm
Bolidson, Jo
United Kingdom, Bristol
University of Bristol
Brismar, Kerstin E.
Sweden, Stockholm
Karolinska Universitetssjukhuset
Brorsson, Caroline Anna B.
Denmark, Gentofte
Hagedorn Research Institute
Carlson, Joyce A.
Sweden, Lund
Skånes Universitetssjukhus
Castaño, Luís Antonio
Spain, Baracaldo
Osakidetza, Cruces University Hospital
Chandler, Kyla A.
United Kingdom, Bristol
University of Bristol
Cherubini, Valentino
Italy, Ancona
Salesi Hospital
Cinek, Ondr̂ej
Czech Republic, Prague
Fakultní Nemocnice V Motole
Cipponeri, Elisa
Italy, Milan
University Campus Bio-medico
Corripio, Raquel
Spain
Consorci Sanitari Parc Taulí
Guja, Cristian
Unknown Affiliation
Gutiérrez, Pilar
Spain, Getafe
Hospital Universitario de Getafe
Heath, Simon C.
France, Evry
Centre National de Recherche en Génomique Humaine
Hernández García, Marta José Rabanaque
Spain, Santa Cruz de Tenerife
Hospital Universitario de Canarias
Ilonen, Jorma S.
Finland, Turku
Turun Yliopisto
Ionescu-Tîrgovişte, Constantin
Unknown Affiliation
Julier, Cécile
France, Evry
Centre National de Recherche en Génomique Humaine
Knip, Mikael
Finland, Helsinki
Helsingin Yliopisto
Kockum, Ingrid Skelton
Sweden, Stockholm
Karolinska Universitetssjukhuset
Kordonouri, Olga
Unknown Affiliation
Ludvigsson, Johnny G.
Unknown Affiliation
Mauricio, Dídac P.
Unknown Affiliation
Phillip, Moshe
Unknown Affiliation
Pirags, Valdis
Latvia, Riga
Paula Stradina Clinical University Hospital
Pociot, Flemming Michael
Denmark, Gentofte
Hagedorn Research Institute
Pozzilli, Paolo
Italy, Milan
University Campus Bio-medico
Roep, Bart O.
Netherlands, Leiden
Leids Universitair Medisch Centrum
Rubio-Cabezas, Óscar
Spain, Madrid
Hospital Infantil Universitario Niño Jesús
Satman, İlhan
Turkey, Istanbul
Istanbul Üniversitesi
Schober, Edith
Unknown Affiliation
Seufert, Jochen R.
Unknown Affiliation
Sobngwi, Eugène
Unknown Affiliation
Spinas, Giatgen Andreia
Unknown Affiliation
Šumník, Zdeněk
Czech Republic, Prague
Fakultní Nemocnice V Motole
Tillmann, Vallo
Estonia, Tartu
Tartu Ülikooli Kliinikum
Undlien, Dag Erik
Norway, Oslo
Universitetet I Oslo
van der Auwera, Bart J.R.
Belgium, Brussels
Vrije Universiteit Brussel
Veličkienė, Džilda
Lithuania, Kaunas
Kaunas University of Medicine
Walter, Markus
Unknown Affiliation
Williams, Alistair J.K.
United Kingdom, Bristol
University of Bristol
Ziegler, Anette Gabriele
Unknown Affiliation
Alper, Chester A.
Unknown Affiliation
Becker, Dorothy J.
United States, Pittsburgh
Upmc Children’s Hospital of Pittsburgh
Benoist, Christophe O.
United States, Boston
Joslin Diabetes Center
Berka, Noureddine
Canada, Calgary
Calgary Laboratory Services
Bottini, Nunzio
United States, Los Angeles
University of Southern California
Brickman, Wendy J.
Unknown Affiliation
Concannon, Patrick J.
United States, Charlottesville
University of Virginia
Couch, Robert M.
Canada, Edmonton
University of Alberta
Dolan, Lawrence M.
United States, Cincinnati
Cincinnati Children's Hospital Medical Center
Doria, Alessandro
United States, Boston
Joslin Diabetes Center
Fain, Pamela R.
United States, Denver
Barbara Davis Center for Childhood Diabetes
Geraghty, Daniel E.
United States, Seattle
Fred Hutchinson Cancer Center
Greenbaum, Carla J.
United States, Seattle
Benaroya Research Institute at Virginia Mason
Hagopian, William A.
United States, Woodinville
University of Washington
Håkonarson, Håkon H.
United States, Seattle
University of Washington
Hansen, John A.
United States, Seattle
Fred Hutchinson Cancer Center
Kaiserman, Kevin B.
United States, Los Angeles
Children's Hospital Los Angeles
Lane, Julie Ann
United States, Oakland
Children's Hospital Oakland Research Institute
Lawrence, Jean M.
United States, Lincoln
University of Nebraska–lincoln
Moonsamy, Priscilla V.
United States, Pleasanton
Roche Molecular Systems
Moran, Antoinette M.
United States, Minneapolis
University of Minnesota Twin Cities
Noble, Janelle Annette
United States, Oakland
Children's Hospital Oakland Research Institute
Önengüt-Gümüşcü, Suna
United States, Charlottesville
University of Virginia
Orbán, Tihamér
United States, Boston
Joslin Diabetes Center
Paterson, Andrew D.
Canada, Toronto
University of Toronto
Pietropaolo, Massimo
United States, Ann Arbor
University of Michigan Medical School
Pihoker, Catherine M.
United States, Madisonville
Regional Medical Center
Polychronakos, Constantin
Canada, Montreal
Centre Universitaire de Santé Mcgill
Pugliese, Alberto
United States, Coral Gables
University of Miami
Qu, Huiqi
Canada, Montreal
Centre Universitaire de Santé Mcgill, Hôpital de Montreal Pour Enfants
Schatz, Desmond A.
United States, Gainesville
University of Florida
She, Jinxiong
United States, Augusta
Medical College of Georgia
Steck, Andrea K.
United States, Denver
Barbara Davis Center for Childhood Diabetes
Taback, Shayne P.
Canada, Winnipeg
University of Manitoba
Willi, Steven M.
Unknown Affiliation
Young, Neal S.
United States, Bethesda
National Institutes of Health Nih
Yu, Liping
United States, Denver
Barbara Davis Center for Childhood Diabetes
Allen, Jamie E.
United Kingdom, Cambridge
University of Cambridge
Barrett, Jeffrey C.
United Kingdom, Cambridge
University of Cambridge
Clayton, David F.
United Kingdom, Cambridge
University of Cambridge
Cooper, Jason D.
United Kingdom, Cambridge
University of Cambridge
Cucca, Francesco
Italy, Sassari
Università Degli Studi Di Sassari
Downes, Kate A.
United Kingdom, Cambridge
University of Cambridge
Dunger, David B.
United Kingdom, Cambridge
University of Cambridge
Field, Sarah F.
United Kingdom, Cambridge
University of Cambridge
Howson, Joanna M.M.
United Kingdom, Cambridge
University of Cambridge
Plagnol, Vincent
United Kingdom, Cambridge
University of Cambridge
Todd, John A.
United Kingdom, Cambridge
University of Cambridge
Tuomilehto, Jaakko O.I.
Finland, Helsinki
Terveyden ja Hyvinvoinnin Laitos
Wicker, Linda S.
United Kingdom, Cambridge
University of Cambridge
Chen, Weimin
United States, Charlottesville
University of Virginia
Hepler, John
United States, Winston Salem
Wake Forest University Health Sciences
Lohman, Kurt K.
United States, Winston Salem
Wake Forest University Health Sciences
Mychaleckyj, Josyf C.
United States, Charlottesville
University of Virginia
Rich, Stephen S.
United States, Charlottesville
University of Virginia
Rushing, Scott
United States, Winston Salem
Wake Forest University Health Sciences
Sale, Michèle M.
United States, Charlottesville
University of Virginia
Snively, Beverly M.
United States, Winston Salem
Wake Forest University Health Sciences
Altshuler, David M.
United States, Cambridge
Whitehead Institute
Bain, Stephen C.
United Kingdom, Swansea
Swansea University
Barcellos, Lisa F.
United States, Berkeley
University of California, Berkeley
Briggs, Farren Basil Shaw
United States, Berkeley
University of California, Berkeley
Daly, Mark J.
United States, Boston
Massachusetts General Hospital
de Bakker, Paul I.W.
United States, Boston
Massachusetts General Hospital
Deloukas, Panos
United Kingdom, Hinxton
Wellcome Sanger Institute
Devlin, Bernie
United States, Pittsburgh
University of Pittsburgh
Field, Lanora Leigh
Canada, Vancouver
The University of British Columbia
Gabriel, Stacey Bolk
United States, Cambridge
Broad Institute
Gaudieri, S.
Australia, Perth
Murdoch University
Gorodezky, C.
Unknown Affiliation
Humphreys, Keith
Sweden, Stockholm
Karolinska Institutet
James, Ian R.
Australia, Perth
Murdoch University
Lathrop, Mark G.
France, Evry
Centre National de Recherche en Génomique Humaine
Mack, Steven J.
United States, Pleasanton
Roche Molecular Systems
McGinnis, Ralph E.
United Kingdom, Hinxton
Wellcome Sanger Institute
McLaren, William M.
United Kingdom, Hinxton
Wellcome Sanger Institute
Ott, Jürg
United States, New York
Rockefeller University
Patterson, Chris C.
United Kingdom, Belfast
Queen's University Belfast
Risch, Neil J.
United States, San Francisco
University of California, San Francisco
Single, Richard M.
United States, Burlington
The University of Vermont
Thomson, Glenys J.
United States, Berkeley
University of California, Berkeley
Vandiedonck, Claire
United Kingdom, Oxford
The Wellcome Centre for Human Genetics
Whittaker, Pamela
United Kingdom, Hinxton
Wellcome Sanger Institute
Zhang, Qingrun
China, Beijing
Beijing Institute of Genomics Chinese Academy of Sciences China National Center for Bioinformation
Statistics
Citations: 15
Authors: 211
Affiliations: 152
Identifiers
Doi:
10.1177/1740774510373497
ISSN:
17407745
Research Areas
Genetics And Genomics
Noncommunicable Diseases
Study Design
Grounded Theory