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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
Sequence and functional analyses of Haemophilus spp. genomic islands
Genome Biology, Volume 8, No. 11, Article R237, Year 2007
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Description
Background: A major part of horizontal gene transfer that contributes to the diversification and adaptation of bacteria is facilitated by genomic islands. The evolution of these islands is poorly understood. Some progress was made with the identification of a set of phylogenetically related genomic islands among the Proteobacteria, recognized from the investigation of the evolutionary origins of a Haemophilus influenzae antibiotic resistance island, namely ICEHin1056. More clarity comes from this comparative analysis of seven complete sequences of the ICEHin1056 genomic island subfamily. Results: These genomic islands have core and accessory genes in approximately equal proportion, with none demonstrating recent acquisition from other islands. The number of variable sites within core genes is similar to that found in the host bacteria. Furthermore, the GC content of the core genes is similar to that of the host bacteria (38% to 40%). Most of the core gene content is formed by the syntenic type IV secretion system dependent conjugative module and replicative module. GC content and lack of variable sites indicate that the antibiotic resistance genes were acquired relatively recently. An analysis of conjugation efficiency and antibiotic susceptibility demonstrates that phenotypic expression of genomic island-borne genes differs between different hosts. Conclusion: Genomic islands of the ICEHin1056 subfamily have a longstanding relationship with H. influenzae and H. parainfluenzae and are co-evolving as semi-autonomous genomes within the 'supragenomes' of their host species. They have promoted bacterial diversity and adaptation through becoming efficient vectors of antibiotic resistance by the recent acquisition of antibiotic resistance transposons. © 2007 Juhas et al.; licensee BioMed Central Ltd.
Authors & Co-Authors
Juhas, Mario
United Kingdom, Oxford
University of Oxford Medical Sciences Division
Power, Peter M.
United Kingdom, Oxford
Mrc Weatherall Institute of Molecular Medicine
Harding, Rosalind
United Kingdom, Oxford
University of Oxford
Ferguson, David J. P.
United Kingdom, Oxford
University of Oxford
Dimopoulou, Ioanna D.
United Kingdom, Oxford
University of Oxford Medical Sciences Division
Elamin, Abdel R.E.
United Kingdom, Oxford
University of Oxford Medical Sciences Division
Mohd-Zain, Zaini
Malaysia, Shah Alam
Universiti Teknologi Mara
Hood, Derek W.
United Kingdom, Oxford
Mrc Weatherall Institute of Molecular Medicine
Adegbola, Richard A.
Gambia, Banjul
Medical Research Council Laboratories Gambia
Erwin, Alice
United States, Seattle
University of Washington
Smith, Arnold Lee
United States, Seattle
University of Washington
Munson, Robert S.
United States, Columbus
The Ohio State University
Harrison, Alistair
United States, Columbus
The Ohio State University
Mansfield, Lucielle
United Kingdom, Hinxton
Wellcome Sanger Institute
Bentley, Stephen D.
United Kingdom, Oxford
Churchill Hospital
Crook, Derrick W.
United Kingdom, Oxford
University of Oxford Medical Sciences Division
Statistics
Citations: 16
Authors: 16
Affiliations: 9
Identifiers
Doi:
10.1186/gb-2007-8-11-r237
ISSN:
14747596
e-ISSN:
1474760X
Research Areas
Genetics And Genomics