Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Antischistosomal efficacy of artesunate combination therapies administered as curative treatments for malaria attacks
Transactions of the Royal Society of Tropical Medicine and Hygiene, Volume 101, No. 2, Year 2007
Notification
URL copied to clipboard!
Description
Artesunate is a highly effective antimalarial and there is some evidence that it is also active against schistosome infections. We therefore investigated whether treatment with artesunate of acute malaria in Senegalese children had an impact on their level of infection with Schistosoma haematobium. Twenty-seven children who were entered into a clinical trial of antimalaria treatment were excreting S. haematobium eggs in their urine on the day of treatment. Fifteen children received a combination of a single dose of sulfadoxine/pyrimethamine together with three daily doses of artesunate (4 mg/kg); the remaining 12 children received three daily doses of amodiaquine and artesunate. The overall cure rate and reduction in the mean number of excreted eggs at 28 days post treatment were 92.6% and 94.5%, respectively. Our findings indicate that artesunate, in addition to being a very effective treatment for uncomplicated malaria, can also sharply reduce the S. haematobium loads harboured by pre-school African children. © 2006.
Authors & Co-Authors
Boulanger, Denis
Unknown Affiliation
Dièng, Yémou D.
Unknown Affiliation
Cisse, Badara
Unknown Affiliation
Remoué, Franck J.
Unknown Affiliation
Capuano, Frederic
Unknown Affiliation
Diémé, Jean Louis
Unknown Affiliation
Ndiaye, Tofène
Unknown Affiliation
Sokhna, Cheikh Sadibou
Unknown Affiliation
Trape, Jean François
Unknown Affiliation
Greenwood, Brian M.
Unknown Affiliation
Simondon, François
Unknown Affiliation
Statistics
Citations: 11
Authors: 11
Affiliations: 4
Identifiers
Doi:
10.1016/j.trstmh.2006.03.003
ISSN:
00359203
Research Areas
Infectious Diseases
Maternal And Child Health