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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
A randomized, placebo-controlled trial of creatine in children with spinal muscular atrophy
Journal of Clinical Neuromuscular Disease, Volume 8, No. 3, Year 2007
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Description
OBJECTIVE: To determine whether oral creatine produces positive changes in any of 4 outcomes in children with spinal muscular atrophy (SMA). METHODS: The authors conducted a randomized, double-blind, placebo-controlled trial on 55 patients aged 2-18 years with SMA. Patients aged younger than 5 years received 2 g/day of creatine/placebo for 6 months. Patients aged 5 years and older received 5 g/day. The primary outcome measure was the Gross Motor Function Measure (GMFM). Secondary outcome measures were Quantitative Muscle Testing (QMT), Parent Questionnaire for the PedsQL™ Neuromuscular Module (QOL), and Pulmonary Function Tests (PFT). RESULTS: Forty of the 55 patients completed the protocol. There was no significant difference in the 4 outcome measures between creatine and placebo groups. CONCLUSIONS: Under the experimental conditions of our study, creatine supplementation for 6 months did not improve motor function, muscle strength, pulmonary function, or quality of life in children with SMA. © 2007 Lippincott Williams & Wilkins, Inc.
Authors & Co-Authors
Iannaccone, Susan T.
United States, Dallas
Ut Southwestern Medical Center
United States, Dallas
Children's Medical Center Dallas
Hynan, Linda S.
United States, Dallas
Ut Southwestern Medical Center
Luckett, Peter M.
United States, Dallas
Ut Southwestern Medical Center
Mayhew, Jill E.
Unknown Affiliation
Smith, Stephen A.
United States, Minneapolis
Gillette Children's Specialty Healthcare
Moy, Claudia Scala
Unknown Affiliation
Newton, Charles R.J.C.
Unknown Affiliation
Statistics
Citations: 19
Authors: 7
Affiliations: 5
Identifiers
Doi:
10.1097/CND.0b013e3180315c99
ISSN:
15371611
Research Areas
Disability
Health System And Policy
Maternal And Child Health
Study Approach
Quantitative