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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Frequency of Distinguishing Clinical Features in Vogt-Koyanagi-Harada Disease
Ophthalmology, Volume 117, No. 3, Year 2010
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Description
Purpose: To determine the frequency of occurrence of limited clinical features which distinguish patients with Vogt-Koyanagi-Harada (VKH) disease from those with non-VKH uveitis. Design: Comparative case series. Participants: We included 1147 patients. Methods: All patients with bilateral ocular inflammatory disease presenting to any of 10 uveitis centers in the 3-month period between January 1 and March 31, 2006 (inclusive), were asked to participate. The clinical and historical features of disease were obtained from the participants via direct interview and chart review. Patients were stratified based on whether they were diagnosed with VKH disease or non-VKH uveitis for statistical analysis. Main Outcome Measures: Presence or absence of various clinical features in the 2 populations. Results: Of 1147 patients, 180 were diagnosed with VKH disease and 967 with non-VKH uveitis. Hispanics and Asians were more likely to be diagnosed with VKH than non-VKH disease compared with other ethnicities. In acute disease, the finding of exudative retinal detachment was most likely to be found in VKH disease with a positive predictive value (PPV) of 100 and negative predictive value (NPV) of 88.4, whereas in chronic disease, sunset glow fundus was most likely to be found, with a PPV of 94.5 and NPV of 89.2. Conclusions: Numerous clinical findings have been described in the past as important in the diagnosis of VKH. The current study reveals that of these, 2 are highly specific to this entity in an ethnically and geographically diverse group of patients with nontraumatic bilateral uveitis. These clinical findings are exudative retinal detachment during acute disease and sunset glow fundus during the chronic phase of the disease. Financial Disclosure(s): Proprietary or commercial disclosures may be found after the references. © 2010 American Academy of Ophthalmology.
Authors & Co-Authors
Rao, Narsing A.
Unknown Affiliation
Gupta, Amod
Unknown Affiliation
Dustin, Laurie
Unknown Affiliation
Chee, Soon Phaik
Unknown Affiliation
Okada, Annabelle A.
Unknown Affiliation
Khairallah, Moncef
Unknown Affiliation
Bodaghi, Bahram
Unknown Affiliation
LeHoang, Phuc
Unknown Affiliation
Accorinti, Massimo
Unknown Affiliation
Mochizuki, Manabu
Unknown Affiliation
Prabriputaloong, Tisha
Unknown Affiliation
Read, Russell W.
Unknown Affiliation
Statistics
Citations: 158
Authors: 12
Affiliations: 11
Identifiers
Doi:
10.1016/j.ophtha.2009.08.030
Research Areas
Health System And Policy
Study Approach
Quantitative