Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Diagnostic microbiologic methods in the GEMS-1 case/control study
Clinical Infectious Diseases, Volume 55, No. SUPPL. 4, Year 2012
Notification
URL copied to clipboard!
Description
To understand the etiology of moderate-to-severe diarrhea among children in high mortality areas of sub-Saharan Africa and South Asia, we performed a comprehensive case/control study of children aged <5 years at 7 sites. Each site employed an identical case/control study design and each utilized a uniform comprehensive set of microbiological assays to identify the likely bacterial, viral and protozoal etiologies. The selected assays effected a balanced consideration of cost, robustness and performance, and all assays were performed at the study sites. Identification of bacterial pathogens employed streamlined conventional bacteriologic biochemical and serological algorithms. Diarrheagenic Escherichia coli were identified by application of a multiplex polymerase chain reaction assay for enterotoxigenic, enteroaggregative, and enteropathogenic E. coli. Rotavirus, adenovirus, Entamoeba histolytica, Giardia enterica, and Cryptosporidium species were detected by commercially available enzyme immunoassays on stool samples. Samples positive for adenovirus were further evaluated for adenovirus serotypes 40 and 41. We developed a novel multiplex assay to detect norovirus (types 1 and 2), astrovirus, and sapovirus. The portfolio of diagnostic assays used in the GEMS study can be broadly applied in developing countries seeking robust cost-effective methods for enteric pathogen detection. © 2012 The Author 2012. Published by Oxford University Press on behalf of the Infectious Diseases Society of America.
Authors & Co-Authors
Panchalingam, Sandra
United States, Baltimore
University of Maryland School of Medicine
Antonio, Martin
Gambia, Banjul
Medical Research Council Laboratories Gambia
Hossain, Anowar K.M.Tanvir
Bangladesh, Dhaka
International Centre for Diarrhoeal Disease Research Bangladesh
Mandomando, Inácio M.
Mozambique, Manhica
Centro de Investigação em Saúde de Manhiça Cism
Ochieng, Benjamin Jack Otieno
Kenya, Nairobi
Kenya Medical Research Institute
Oundo, Joseph Wang Ang’a A.
Kenya, Nairobi
Kenya Medical Research Institute
Ramamurthy, Thandavarayan
India, Kolkata
National Institute of Cholera and Enteric Diseases India
Tamboura, Boubou
Mali, Bamako
Center for Vaccine Development-mali
Zaidi, Anita Kaniz Mehdi
Pakistan, Karachi
The Aga Khan University
Petri, William A.
United States, Charlottesville
University of Virginia School of Medicine
Houpt, Eric R.
United States, Charlottesville
University of Virginia School of Medicine
Murray, Patrick R.
United States, Atlanta
Centers for Disease Control and Prevention
Prado, Valeria
Chile, Santiago
Universidad de Chile
Vidal, Roberto
Chile, Santiago
Universidad de Chile
Steele, Duncan A.
Switzerland, Geneva
Organisation Mondiale de la Santé
Strockbine, Nancy A.
United States, Atlanta
Centers for Disease Control and Prevention
Sansonetti, Philippe Jean
France, Paris
Institut Pasteur, Paris
Glass, Roger I.M.
United States, Atlanta
Centers for Disease Control and Prevention
Robins-Browne, Roy Michael
Australia, Melbourne
University of Melbourne
Tauschek, Marija
Australia, Melbourne
University of Melbourne
Svennerholm, Ann Mari L.
Sweden, Gothenburg
Göteborgs Universitet
Kotloff, Karen L.
United States, Baltimore
University of Maryland School of Medicine
Levine, Myron M.
United States, Baltimore
University of Maryland School of Medicine
Nataro, James Paul
United States, Baltimore
University of Maryland School of Medicine
United States, Charlottesville
University of Virginia School of Medicine
Statistics
Citations: 180
Authors: 24
Affiliations: 15
Identifiers
Doi:
10.1093/cid/cis754
ISSN:
10584838
e-ISSN:
15376591
Research Areas
Maternal And Child Health