Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Low retention of HIV-infected patients on antiretroviral therapy in 11 clinical centres in West Africa
Tropical Medicine and International Health, Volume 15, No. SUPPL. 1, Year 2010
Notification
URL copied to clipboard!
Description
Objective To study factors associated with the probability of retention in antiretroviral therapy (ART) programmes in West Africa. Methods The International epidemiologic Databases to Evaluate AIDS (IeDEA) in West Africa is a prospective, operational, observational cohort study based on collaboration between 11 cohorts of HIV-infected adult patients in Benin, Côte d'Ivoire, Gambia, Mali and Senegal. All patients aged 16 and older at ART initiation, with documented gender and date of ART initiation, were included. For those with at least 1 day of follow-up, Kaplan-Meier method and Weibull regression model were used to estimate the 12-month probability of retention in care and the associated factors. Results In this data merger, 14 352 patients (61% female) on ART were included. Median age was 37 (interquartile range (IQR): 31-44 years) and median CD4 count at baseline was 131 cells/mm3 (IQR: 48-221 cells/mm3). The first-line regimen was NNRTI-based for 78% of patients, protease inhibitor-based for 17%, and three NRTIs for 3%. The probability of retention was 0.90 [95% confidence interval (CI): 0.89-0.90] at 3 months, 0.84 (95% CI: 0.83-0.85) at 6 months and 0.76 (95% CI: 0.75-0.77) at 12 months. The probability of retention in care was lower in patients with baseline CD4 count <50 cells/mm3 [adjusted hazard ratio (aHR) = 1.37; 95% CI: 1.27-1.49; P < 0.0001] (reference CD4 > 200 cells/mm 3, in men (aHR = 1.17; 95% CI: 1.10-1.24; P = 0.0002), in younger patients (<30 years) (aHR = 1.10; 95% CI: 1.03-1.19; P = 0.01) and in patients with low haemoglobinaemia <8 g/dl (aHR = 1.33; 95% CI: 1.21-1.45; P < 0.0001). Availability of funds for systematic tracing was associated with better retention (aHR = 0.29; 95% CI: 0.16-0.55; P = 0.001). Conclusions Close follow-up, promoting early access to care and ART and a decentralized system of care may improve the retention in care of HIV-infected patients on ART. © 2010 Blackwell Publishing Ltd.
Authors & Co-Authors
Ékouévi, Didier Koumavi
France, Paris
Inserm
Cote D'ivoire, Abidjan
Centre Hospitalier Universitaire de Treichville
Balestre, Eric
France, Paris
Inserm
Ba-Gomis, Franck Olivier
Cote D'ivoire, Abidjan
Centre Intégré de Recherches Biocliniques D'abidjan Cirba
Eholié, Serge Paul
Cote D'ivoire, Abidjan
Centre Hospitalier Universitaire de Treichville
Maïga, Moussa Youssouffa
Mali, Bamako
Hopital Gabriel Toure
Amani-Bossé, Clarisse
Cote D'ivoire, Abidjan
Aconda
Minga, Albert Kla
Cote D'ivoire, Abidjan
Centre Hospitalier Universitaire de Treichville
Cote D'ivoire, Abidjan
Centre Médical de Suivi de Donneurs de Sang/cnts/primo-ci
Messou, Eugéne
Cote D'ivoire, Abidjan
Aconda
Sow, Papa Salif
Senegal, Dakar
Centre Hospitalier Universitaire Dakar
Lewden, Charlotte
France, Paris
Inserm
Traoré, Hammar Alassane
Mali, Bamako
Hopital National du Point g
Bissagnéné, Emmanuel
Cote D'ivoire, Abidjan
Centre Hospitalier Universitaire de Treichville
Dabis, Franćois Ç.Ois
France, Paris
Inserm
Statistics
Citations: 89
Authors: 13
Affiliations: 8
Identifiers
Doi:
10.1111/j.1365-3156.2010.02505.x
ISSN:
13602276
e-ISSN:
13653156
Research Areas
Environmental
Health System And Policy
Infectious Diseases
Study Design
Cohort Study
Study Approach
Quantitative
Study Locations
Multi-countries
Benin
Gambia
Ivory Coast
Mali
Senegal
Participants Gender
Male
Female