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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Effects of maternal multiple micronutrient supplementation on fetal growth: A double-blind randomized controlled trial in rural Burkina Faso
American Journal of Clinical Nutrition, Volume 88, No. 5, Year 2008
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Description
Background: Intrauterine growth retardation is a major predictor of child health in developing countries. Objective: We tested whether providing pregnant women with the UNICEF/WHO/UNU international multiple micronutrient preparation (UNIMMAP), rather than iron and folic acid alone, improved fetal growth and its correlates. Design: An intention-to-treat, double-blind, randomized controlled trial including 1426 pregnancies was carried out in rural Burkina Faso. Tablet intake was directly observed. Results: Pregnancy outcome was known in 96.3% of the participants. After adjustment for gestational age at delivery, both birth weight (52 g; 95% CI: 4, 100; P = 0.035) and birth length (3.6 mm; 95% CI: 0.8, 6.3; P = 0.012) were significantly higher in the UNIMMAP group. UNIMMAP had a differential effect by percentiles of birth weight and length distributions: the risk of large-forgestational-age infants was higher in the UNIMMAP group (OR: 1.58; 95% CI: 1.04, 2.38; P = 0.03), although the risk of low birth weight remained unchanged. The effect of UNIMMAP on birth size was modified by maternal body mass index at enrollment and could be more important in multiparous women and women taking sulfadoxine-pyrimethamine. Unexpectedly, the risk of perinatal death was marginally significantly increased in the UNIMMAP group (OR: 1.78; 95% CI: 0.95, 3.32; P = 0.07), and this seemed to affect mainly primiparous women (OR: 3.44; 95% CI: 1.1, 10.7; P for interaction = 0.11). Conclusions: Maternal UNIMMAP modestly but significantly increased fetal growth. The resulting benefit on infant growth and survival needs to be assessed. The possible lack of benefit and potential harm in primiparous women should be further investigated. This trial was registered at clinicaltrials.gov as NCT00642408. © 2008 American Society for Nutrition.
Authors & Co-Authors
Roberfroid, Dominique Albert
Belgium, Antwerpen
Prins Leopold Instituut Voor Tropische Geneeskunde
Huybregts, Lieven Fernand
Burkina Faso, Ouagadougou
Centre Muraz
Lanou, Hermann Biénou
Belgium, Ghent
Universiteit Gent
Henry, Marie Claire
Burkina Faso, Ouagadougou
Centre Muraz
Méda, Nicolas Yelbomkan
Burkina Faso, Ouagadougou
Centre Muraz
Menten, Joris
Belgium, Antwerpen
Prins Leopold Instituut Voor Tropische Geneeskunde
Kolsteren, Patrick Wilfried V.J.
Belgium, Antwerpen
Prins Leopold Instituut Voor Tropische Geneeskunde
Ki, J. P.
Unknown Affiliation
Koudougbo, V.
Unknown Affiliation
Toe, Laeticia Celine
Unknown Affiliation
Da, E.
Unknown Affiliation
Lougue, Guekoun
Unknown Affiliation
Negalo, B.
Unknown Affiliation
Guebe, O.
Unknown Affiliation
Hien, B.
Unknown Affiliation
Ouattara, Siaka
Unknown Affiliation
Bicaba, Brice Wilfried
Unknown Affiliation
Kouakou Yameogo, C.
Unknown Affiliation
Diallo, N.
Unknown Affiliation
Sanou, Michel
Unknown Affiliation
Hien, Alain D.
Unknown Affiliation
Kusin, Jane A.
Netherlands, Amsterdam
Universiteit Van Amsterdam
Delpeuch, Francis
France, Montpellier
Ird Centre de Montpellier
van Camp, John Hendrik
Belgium, Ghent
Universiteit Gent
Bourdoux, Pierre P.
Belgium, Brussels
Université Libre de Bruxelles
Diagbouga, Serge P.
Burkina Faso, Ouagadougou
Centre Muraz
Tapsoba, S.
Burkina Faso, Health
Ministry of Public
Boncoungou, Mete
Unknown
Ministry of Public Health
Nikièma, Philippe Augustin
Burkina Faso, Ouagadougou
University of Ouagadougou
Statistics
Citations: 156
Authors: 29
Affiliations: 9
Identifiers
Doi:
10.3945/ajcn.2008.26296
ISSN:
00029165
Research Areas
Disability
Food Security
Maternal And Child Health
Sexual And Reproductive Health
Study Approach
Quantitative
Study Locations
Burkina Faso
Participants Gender
Female