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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
Estimation of the sequestered parasite load in severe malaria patients using both host and parasite markers
Parasitology, Volume 131, No. 4, Year 2005
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Description
The virulence of the malaria parasite Plasmodium falciparum is due, in part, to its ability to cytoadhere in deep vascular beds. Our inability to quantify the load of sequestered parasites hampers our understanding of the pathophysiological mechanisms involved in disease progression and complicates diagnosis. In this study we evaluate potential biochemical markers of sequestered load by comparing them with estimates of the sequestered load from a statistical model fitted to longitudinal patterns of peripheral parasite densities in a series of 22 patients with severe Plasmodium falciparum malaria. The markers comprised the host factors: haematocrit, circulating host DNA, sTNF-R75 and parasite derived products HRP2, pLDH, pigments and circulating parasite DNA. We investigated the suitability of these markers in determining sequestered loads in patients on quinine treatment. Observed peripheral parasitaemia, plasma levels of sTNF-R75 and circulating parasite DNA were most strongly correlated with estimates of sequestered loads on admission. However the dynamics of both sTNF-R75 and circulating parasite DNA during follow-up were very different from those of the estimated sequestered mass. These analyses suggest that none of the markers gave reliable estimates of the current sequestered load, though they may reflect the history of infection. Longitudinal analyses are needed that allow for the clearance rates of the marker molecules and for variations between hosts in the history of parasitaemia. © 2005 Cambridge University Press.
Authors & Co-Authors
Ochola, Lucy B.
Switzerland, Allschwil
Swiss Tropical and Public Health Institute Swiss Tph
Kenya, Kilifi
Centre for Geographic Medicine Research
Marsh, Kevin
Kenya, Kilifi
Centre for Geographic Medicine Research
United Kingdom, Oxford
Nuffield Department of Medicine
Lowe, Brett S.
Kenya, Kilifi
Centre for Geographic Medicine Research
Gal, S.
United Kingdom, Oxford
Nuffield Department of Medicine
Pluschke, Gerd
Switzerland, Allschwil
Swiss Tropical and Public Health Institute Swiss Tph
Smith, Thomas A.
Switzerland, Allschwil
Swiss Tropical and Public Health Institute Swiss Tph
Statistics
Citations: 54
Authors: 6
Affiliations: 3
Identifiers
Doi:
10.1017/S0031182005008085
e-ISSN:
14698161
Research Areas
Genetics And Genomics
Infectious Diseases
Study Design
Cohort Study