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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Safety of DNA and modified vaccinia virus Ankara vaccines against liver-stage P. falciparum malaria in non-immune volunteers
Vaccine, Volume 21, No. 17-18, Year 2003
Notification
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Description
A series of phase I clinical studies were conducted to evaluate the safety of plasmid DNA and modified vaccinia virus Ankara malaria vaccines. The vaccines each encoded a polyepitope string fused to whole Plasmodium falciparum TRAP antigen. Forty-three healthy adult volunteers received the vaccines alone or in DNA/MVA prime-boost combinations. The DNA vaccine was administered either intramuscularly by needle or intradermally by a needleless delivery device. The MVA vaccine was administered intradermally by needle. The vaccines were well-tolerated by all three routes and in various DNA/MVA immunisation regimes. There were no severe or serious adverse events. © 2002 Elsevier Science Ltd. All rights reserved.
Authors & Co-Authors
Moorthy, Vasee S.
United Kingdom, Oxford
Nuffield Department of Medicine
Gambia, Banjul
Medical Research Council Laboratories Gambia
McConkey, Samuel J.
United Kingdom, Oxford
Nuffield Department of Medicine
Roberts, Mark T.M.
United Kingdom, Oxford
Nuffield Department of Medicine
Gothard, Philip K.
United Kingdom, Oxford
Nuffield Department of Medicine
Arulanantham, Nirmalan
United Kingdom, Oxford
Nuffield Department of Medicine
Degano, P.
United Kingdom, Oxford
Nuffield Department of Medicine
Schneider, Jörg
United Kingdom, Oxford
Nuffield Department of Medicine
Hannan, Carolyn M.
United Kingdom, Oxford
Nuffield Department of Medicine
Roy, Michael J.
United States, Madison
Powderject Vaccines
Gilbert, Sarah C.
United Kingdom, Oxford
Nuffield Department of Medicine
Peto, Timothy E.A.
United Kingdom, Oxford
Nuffield Department of Medicine
Hill, Adrian V. S.
United Kingdom, Oxford
Nuffield Department of Medicine
Statistics
Citations: 12
Authors: 12
Affiliations: 3
Identifiers
Doi:
10.1016/S0264-410X(02)00771-5
ISSN:
0264410X
Research Areas
Genetics And Genomics
Infectious Diseases