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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Etiologies and characteristics of refractory status epilepticus cases in different areas of the world: Results from a global audit
Epilepsia, Volume 59, Year 2018
Notification
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Description
To describe the demographics, etiologies, types of status epilepticus (SE), and outcomes in people with refractory and super-refractory SE from around the world, we prospectively collected cases of refractory SE (RSE) treated with continuous intravenous anesthetic drugs in an intensive care unit setting through online questionnaires using “active surveillance.” We collected information about 776 cases of RSE in 50 countries over 4 years. Control of SE was achieved in 74% of the cases. Neurologic outcomes were poor in 41% of patients, and 24% died. Good outcome was associated with younger age and a history of epilepsy. Etiology strongly influenced the outcome. Patients from Asia were younger, more frequently presented with convulsive SE, and were more frequently affected by infectious etiologies when compared with patients from Europe and the Americas. Despite these differences, outcomes were similar in all countries. Demographics of patients with RSE in a global audit are similar to those in prior single center series, providing evidence of generalizability of those studies. Important differences exist among patients with RSE from different regions of the world, but these do not seem to significantly influence patient outcomes. Wiley Periodicals, Inc. © 2018 International League Against Epilepsy
Authors & Co-Authors
Hocker, Sara E.
United States, Rochester
Mayo Clinic
Trinka, Eugen
Austria, Salzburg
Paracelsus Medizinische Privatuniversitat
Shorvon, Simon D.
United Kingdom, London
National Hospital for Neurology and Neurosurgery
Singh, Gagandeep P.I.
Unknown Affiliation
Kälviäinen, Reetta K. K.
Unknown Affiliation
Newton, Charles R.J.C.
Unknown Affiliation
O'Brien, Terence J.
Unknown Affiliation
Cook, Mark James
Unknown Affiliation
Groppa, Stanislav A.
Unknown Affiliation
Kumlien, Eva
Unknown Affiliation
Nabbout, Rima C.
Unknown Affiliation
Tripathi, Manjari N.
Unknown Affiliation
Samarasekera, Shanika R.
Unknown Affiliation
Giovannini, Giada
Unknown Affiliation
Baheti, Neeraj N.
Unknown Affiliation
Reinikainen, Matti T.
Unknown Affiliation
Statistics
Citations: 15
Authors: 16
Affiliations: 4
Identifiers
Doi:
10.1111/epi.14496
ISSN:
00139580
Research Areas
Health System And Policy