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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Adding phytoestrogens to clomiphene induction in unexplained infertility patients - A randomized trial
Reproductive BioMedicine Online, Volume 16, No. 4, Year 2008
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Description
This study investigated the role of oral phytoestrogens in improving pregnancy rate and cycle outcomes with clomiphene citrate. Patients with unexplained infertility and recurrent clomiphene citrate induction failure, were randomly divided into two groups: group I (n = 60) and group II (n = 59). Both groups received clomiphene citrate 150 mg per day (days 3 to 7). Group I received additional oral phytoestrogen (Cimicifuga racemosa) 120 mg/day from days 1 to 12. Human chorionic gonadotrophin (HCG) injection (10,000 IU i.m.) was given and timed intercourse was recommended when a leading follicle reached >17 mm and serum oestradiol exceeded 200 (pg/ml). There was a non-significant shortening of induction cycles in group I. Oestradiol and LH concentrations were higher in group I compared with group II. Endometrial thickness, serum progesterone and clinical pregnancy rate were significantly higher in group I (8.9 ± 1.4mm versus 7.5 ± 1.3 mm, P <0.001; 13.3 ± 3.1 ng/ml versus 9.3 ± 2.0 ng/ml, P <0.01; 36.7% versus 13.6%, P <0.01, respectively). It is concluded that adding C. racemosa rhizome dry extract to clomiphene citrate induction can improve the pregnancy rate and cycle outcomes in these couples. © 2008 Published by Reproductive Healthcare Ltd.
Authors & Co-Authors
Shahin, Ahmed Youssif
Egypt, Asyut
Assiut University
Ismail, Alaa Mahmoud
Egypt, Asyut
Assiut University
Zahran, Kamal Mohammed
Egypt, Asyut
Assiut University
Makhlouf, Ahmad Mohammad
Egypt, Asyut
Assiut University
Statistics
Citations: 51
Authors: 4
Affiliations: 1
Identifiers
Doi:
10.1016/S1472-6483(10)60465-8
ISSN:
14726483
Research Areas
Health System And Policy
Maternal And Child Health
Sexual And Reproductive Health