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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Clinical outcome in bipolar disorder in a community-based follow-up study in Butajira, Ethiopia
Acta Psychiatrica Scandinavica, Volume 114, No. 6, Year 2006
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Description
Objective: To determine the clinical outcome of bipolar disorder in a developing country setup. Method: After assessing 68 378 individuals, aged 15-49 years, in a double-sampling design in a rural community in Ethiopia, 312 patients with bipolar disorder were prospectively monitored with symptom rating scales and clinically for an average of 2.5 years. Results: Overall, 65.9% of the cohort experienced a relapse - 47.8% manic, 44.3% depressive and 7.7% mixed episodes - and 31.1% had persistent illness. Female gender predicted depressive relapse, while male gender predicted manic relapse. Being on psychotropic medication was associated with remission. Conclusion: This large community-based study confirms the relapsing nature of bipolar disorder and a tendency for chronicity. This may be partly because of lack of appropriate interventions in this setting; however, it may also indicate the underlying severity of the disorder irrespective of setting. © 2006 The Authors.
Authors & Co-Authors
Fekadu, A.
United Kingdom, London
King's College London
United Kingdom, London
South London and Maudsley Nhs Foundation Trust
Kebede, Derege
Ethiopia, Addis Ababa
Addis Ababa University
Alem, Atalay
Ethiopia, Addis Ababa
Addis Ababa University
Ethiopia, Addis Ababa
School of Medicine
Fekadu, Daniel
United Kingdom, London
King's College London
Mogga, S.
United Kingdom, London
King's College London
Negash, Alemayehu
Ethiopia, Addis Ababa
Addis Ababa University
Medhin, Girmay
Ethiopia, Addis Ababa
Addis Ababa University
Beyero, Teferra
Ethiopia, Addis Ababa
Addis Ababa University
Shibre, Teshome
Ethiopia, Addis Ababa
Addis Ababa University
Statistics
Citations: 46
Authors: 9
Affiliations: 4
Identifiers
Doi:
10.1111/j.1600-0447.2006.00825.x
ISSN:
0001690X
e-ISSN:
16000447
Research Areas
Mental Health
Study Design
Cohort Study
Study Locations
Ethiopia
Participants Gender
Male
Female